|HUSSAIN, SYED - OAK RIDGE INSTITUTE FOR SCIENCE AND EDUCATION (ORISE)|
Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 7/13/2021
Publication Date: N/A
Technical Abstract: Microbial oils have proposed a platform to face the challenges related to food security, global warming, and paucity of non-renewable resources. Medium-chain fatty acids (MCFAs) and their derivatives demonstrate a C8 to C12 chain-length and are engaged in the biosynthesis of premium quality biofuels. These MCFAs also participate in a noteworthy role as promising ingredients for the various biochemical, oleochemical, and nutraceutical industries, for example, the development of detergents, surfactants, bioplasticizers, lubricants, adhesives, perfumes, and precursors for flavor and floral aromas. Also, MCFAs offer uncomplicated assimilation, swift translocation to the liver via the portal veins, and quick metabolism through the ß-oxidation pathway, eventually elevating diet-triggered thermogenesis. This system has facilitated the potential for the prevention and management of diverse metabolic disorders, including atherosclerosis, hypertension, hyperlipidemia, obesity, type-II diabetes, and cardiovascular diseases. Even so, the profusion of naturally produced MCFAs from plant sources is projected to be inadequate to cover the industrial requirement. Therefore, current spotlight has been diverted towards the de novo biosynthesis of MCFAs from diverse oleaginous microorganisms such as Mucor circinelloides, which have been genetically manipulated and optimized the culture conditions to overproduce MCFAs.