Location: Endemic Poultry Viral Diseases ResearchTitle: Family Herpesviridae
|DAVISON, ANDREW - University Of Glasgow|
|DEPLEDGE, DANIEL - New York University School Of Medicine|
|TRIMPERT, JAKOB - Freie University|
|STEWART, JAMES - University Of Liverpool|
|SCHMID, SCOTT - Centers For Disease Control And Prevention (CDC) - United States|
|HARTLEY, CAROL - University Of Melbourne|
|SZPARA, MORIAH - Pennsylvania State University|
|JAROSINSKI, KEITH - University Of Illinois|
|VAZ, PAOLA - Pennsylvania State University|
Submitted to: Journal of General Virology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 8/14/2021
Publication Date: 10/27/2021
Citation: Davison, A.J., Depledge, D.P., Trimpert, J., Stewart, J.P., Spatz, S.J., Schmid, S., Hartley, C.A., Szpara, M.L., Jarosinski, K.W., Vaz, P.K. 2021. Family Herpesviridae. Journal of General Virology. https://doi.org/10.1099/jgv.0.001673.
Interpretive Summary: Herpes viruses are microscopic structures consisting of symmetrical and non-symmetrical components. These viruses contain double-stranded DNA that are125,000–241,000 nucleotides in length. This DNA encodes 70-170 genes . The viruses have generally evolved with their hosts and are highly adapted to them, and are likely to be represented in most animal species. Following primary infection, they are capable of establishing life-long persistent or latent infection. Severe disease is usually observed only in the fetal or very young and the immunocompromised individual. It is also possible to get infected by a herpesvirus whose host is a different species.
Technical Abstract: Members of the family Herpesviridae have enveloped, spherical virions with characteristic complex structures consisting of symmetrical and non-symmetrical components. The linear, double-stranded DNA genomes are 125–241 kbp in size and contain approximately 70-170 genes encoding functional proteins, of which 43 are detectably inherited from an ancestral herpesvirus. The viruses have generally evolved with their hosts and are highly adapted to them, and are likely to be represented in most mammalian, avian and reptilian species. Following primary infection, they are capable of establishing life-long latent infection, during which there is limited viral gene expression. Severe disease is usually observed only in the foetus or very young, the immunocompromised or following infection of an alternative host.