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ARS Home » Plains Area » Houston, Texas » Children's Nutrition Research Center » Research » Publications at this Location » Publication #380587

Research Project: Nutritional Role of Phytochemicals

Location: Children's Nutrition Research Center

Title: Roles of regulatory RNAs in nutritional control

item MCNEILL, ELIZABETH - Iowa State University
item HIRSCHI, KENDAL - Children'S Nutrition Research Center (CNRC)

Submitted to: Annual Review of Nutrition
Publication Type: Review Article
Publication Acceptance Date: 9/15/2020
Publication Date: 9/15/2020
Citation: McNeill, E.M., Hirschi, K.D. 2020. Roles of regulatory RNAs in nutritional control. Annual Review of Nutrition. 40:77-104.

Interpretive Summary:

Technical Abstract: Small RNAs (sRNAs), including microRNAs (miRNAs), are noncoding RNA (ncRNA) molecules involved in gene regulation. sRNAs play important roles in development; however, their significance in nutritional control and as metabolic modulators is still emerging. The mechanisms by which diet impacts metabolic genes through miRNAs remain an important area of inquiry. Recent work has established how miRNAs are transported in body fluids often within exosomes, which are small cell-derived vesicles that function in intercellular communication. The abundance of other recently identified ncRNAs and new insights regarding ncRNAs as dietary bioactive compounds could remodel our understanding about how foods impact gene expression. Although controversial, some groups have shown that dietary RNAs from plants and animals (i.e., milk) are functional in consumers. In the future, regulating sRNAs either directly through dietary delivery or indirectly by altered expression of endogenous sRNA may be part of nutritional interventions for regulating metabolism.