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Research Project: Prevention of Obesity Related Metabolic Diseases by Bioactive Components of Food Processing Waste Byproducts and Mitigation of Food Allergies

Location: Healthy Processed Foods Research

Title: Hypolipidemic effects of dietary fibre from an artichoke by-product in syrian hamsters

item VILLANUEVA-SUAREZ, MARIA JOSE - Complutense University Of Madrid (UCM)
item MATEOS-APARICIO, INMACULADA - Complutense University Of Madrid (UCM)
item PEREZ-COZAR, MARIA LUISA - Complutense University Of Madrid (UCM)
item Yokoyama, Wallace - Wally
item REDONDO-CUENCA, ARACELI - Complutense University Of Madrid (UCM)

Submitted to: Journal of Functional Foods
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 3/9/2019
Publication Date: 3/12/2019
Citation: Villanueva-Suarez, M., Mateos-Aparicio, I., Perez-Cozar, M., Yokoyama, W.H., Redondo-Cuenca, A. 2019. Hypolipidemic effects of dietary fibre from an artichoke by-product in Syrian hamsters. Journal of Functional Foods. 56:156-162.

Interpretive Summary: Artichokes are high in dietary fibers particularly fibers composed of inulin. Hamsters on high fat diets become obese and develop many characteristics of chronic disease in humans including high blood cholesterol and fatty liver. Hamsters on high fed diets supplemented with artichoke had lower levels of “bad” cholesterol in the blood, lower triglyceride in blood and less fat in the liver. These results suggest that artichoke consumption may decrease risk factors for cardiovascular disease and other chronic metabolic diseases.

Technical Abstract: Dietary fibre, including inulin-type fructans, from artichoke by-product were analyzed to understand the potential hypolipidemic effects over Syrian Hamsters fed a high fat diet. A decrease (p < 0.001) of plasma triglycerides (34%), VLDL+LDL (29%) and total cholesterol (24%) was observed in the artichoke supplemented animals. The remarkable cation-exchange and swelling capacities enhances the diminution of intraluminal diffusion and absorption of lipids. The mentioned decrease in sera parameters affects fat accumulation preventing hepatic steatosis. Indeed, a diminution of total fat (21%), total cholesterol (13.6%) (p < 0.05), triglycerides (19%) and esterified cholesterol (33%) (p < 0.01) was observed in liver. Fecal excretion of total fat, triglycerides and bile acids increased (p < 0.001) in treated animals mainly due to the notable oil holding capacity. It is concluded that artichoke by-product has hypolipidemic effects due to the presence of inulin-type fructans in synergy mainly with arabinans and/or arabinogalactans; being this synergy more effective than inulin alone as a lipid-lowering agent.