Author
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Evans, Kervin |
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Compton, David |
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Skory, Christopher |
Submitted to: Pacific Basin Society Chemical International Congress Abstracts
Publication Type: Abstract Only Publication Acceptance Date: 12/16/2020 Publication Date: N/A Citation: N/A Interpretive Summary: Technical Abstract: An increasing need for nanoparticles with the capability of encapsulating hydrophobic materials has led us to develop water-insoluble alpha-glucans into nanoparticles. The alpha-glucans we used are agri-based biopolymers synthesized using recombinant glucansucrase from Leuconostoc mesenteroides. These glucan nanoparticles made through high-pressure homogenization were shown to have a hydrophobic core and have a stability greater than 7 months. The glucan nanoparticles also have characteristic size and surface potential between 110 – 150 nm and -8 to -3 mV, respectively. We have combined the alpha-glucans in a 1-to-2 weight-to-weight ratio with feruloyl soy glycerides, a modified soybean oil, to form a novel feruloyl soy glyceride-glucan (FSGG) nanoparticle system. Analysis shows that the FSGG nanoparticles are about 239 nm in diameter and have a surface potential of about -15.5 mV. FSGG nanoparticles exhibit a stability of at least two weeks, remaining homogenously mixed in water without precipitation. This is the first demonstration of a novel phytochemically modified soybean oil being encapsulated within a nanoparticles system. These combined agri-based molecule and polymer have great potential as a novel, biodegradable delivery system. |