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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #375181

Research Project: Nutrition, Sarcopenia, Physical Function, and Skeletal Muscle Capacity During Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: ICFSR task force perspective on biomarkers for sarcopenia and frailty

item RODRIGUEZ-MANAS, LEOCADIO - Hospital Universitario De Getafe
item ARAUJO DE CARVALHO, ISLENE - World Health Organization (WHO) - Switzerland
item BHASIN, SHALENDER - Brigham & Women'S Hospital
item BISCHOFF-FERRARA, HEIKE - University Of Zurich
item CESARI, MATTEO - University Of Milan
item EVANS, WILLIAM - Duke University
item HARE, JOSHUA - University Of Miami
item PAHOR, MARCO - University Of Florida
item PARINI, ANGELO - Toulouse University Hospital
item ROLLAND, YVES - La Grave Hospital
item FIELDING, ROGER - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item WATSON, JEREMY - Johns Hopkins University
item VELLAS, BRUNO - Toulouse University Hospital

Submitted to: The Journal of Frailty and Aging
Publication Type: Review Article
Publication Acceptance Date: 8/26/2019
Publication Date: 10/7/2019
Citation: Rodriguez-Manas, L., Araujo De Carvalho, I., Bhasin, S., Bischoff-Ferrara, H.A., Cesari, M., Evans, W., Hare, J.M., Pahor, M., Parini, A., Rolland, Y., Fielding, R.A., Watson, J., Vellas, B. 2019. ICFSR task force perspective on biomarkers for sarcopenia and frailty. The Journal of Frailty and Aging. 9(1):4-8.

Interpretive Summary:

Technical Abstract: Biomarkers of frailty and sarcopenia are essential to advance the understanding of these conditions of aging and develop new diagnostic tools and effective treatments. The International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force - a group of academic and industry scientists from around the world - met in February 2019 to discuss the current state of biomarker development for frailty and sarcopenia. The D3Cr dilution method, which assesses creatinine excretion as a biochemical measure of muscle mass, was suggested as a more accurate measure of functional muscle mass than assessment by dual energy x-ray absorptiometry (DXA). Proposed biomarkers of frailty include markers of inflammation, the hypothalamic-pituitary-adrenal (HPA) axis response to stress, altered glucose insulin dynamics, endocrine dysregulation, aging, and others, acknowledging the complex multisystem etiology that contributes to frailty. Lack of clarity regarding a regulatory pathway for biomarker development has hindered progress; however, there are currently several international efforts to develop such biomarkers as tools to improve the treatment of individuals presenting these conditions.