Molecules and polysaccharides from agri-biomass modified via high-pressure homogenization to form nanoparticles and potential nanocarriers

Authors: Evans, Kervin; Compton, David; Price, Neil; Skory, Christopher; Vaughn, Steven; Appell, Michael

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 8/16/2020
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: There is an increasing drive to find agri-based biopolymers that can be transformed into nanoparticles with the potential of being nanocarriers of bioactive molecules. We have explored nanoparticle formation with three agri-based biopolymers that have distinctive properties for different types of nanocarrier applications. A water-soluble polysaccharide, a water-insoluble polysaccharide, and a feruloylated soybean oil were each individually put through high-pressure homogenization to form nanoparticles. The water-soluble polysaccharide was purified from the Vitis riparia Michx Frost grape vine found locally in Illinois. The water-insoluble polysaccharide alpha-glucan was produced from microbial enzymatic synthesis. The feruloylated soy glycerides were synthesized by chemically combining ethyl ferulate with soybean oil. The frost grape polysaccharide formed nanoparticles that were an average of 227 ± 18 nm in diameter, had an average surface potential of -26 ± 1 mV and were stable for more than 21 days. The alpha-glucans formed nanoparticles with a diameter average of 131 ± 24 nm, had a surface potential average of -3.7 ± 4.2 mV and were stable for more than 225 days. The feruloylated soy glycerides formed nanoparticles with an average of diameter of 168 ± 43 nm, an average surface potential of -26.6 ± 3.3 mV and stability over more than 90 days. These materials from renewable biomass show great potential to be developed into highly stable, biodegradable nanocarriers.