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ARS Home » Pacific West Area » Albany, California » Western Regional Research Center » Produce Safety and Microbiology Research » Research » Publications at this Location » Publication #373412

Research Project: Molecular Identification and Characterization of Bacterial and Viral Pathogens Associated with Foods

Location: Produce Safety and Microbiology Research

Title: Complete genome sequence of the novel Campylobacter species “Candidatus Campylobacter infans”

item DUIM, BIRGITTA - Utrecht University
item VAN DER GRAAF, LINDA - Utrecht University
item TIMMERMAN, ARJEN - Utrecht University
item WAGENAAR, JAAP - Utrecht University
item FLIPSE, JACKY - Isala Clinics
item WALLINGA, JANNY - Isala Clinics
item BLOEMBERGEN, PETER - Isala Clinics
item Miller, William - Bill
item ZOMER, ALDERT - Utrecht University

Submitted to: Microbiology Resource Announcements
Publication Type: Other
Publication Acceptance Date: 1/20/2021
Publication Date: 2/18/2021
Citation: Duim, B., Van Der Graaf, L., Timmerman, A., Wagenaar, J.A., Flipse, J., Wallinga, J., Bloembergen, P., Miller, W.G., Zomer, A.L. 2021. Complete genome sequence of the novel Campylobacter species “Candidatus Campylobacter infans”. Microbiology Resource Announcements. 10(7):e00721-20.

Interpretive Summary: Campylobacter is the leading cause of bacterial foodborne illness worldwide. Typically, most campylobacterioses are associated with Campybacter jejuni and Campylobacter coli, although other Campylobacter species have been implicated in serious illness. In addition to severe diarrheal disease, pediatric infection with Campylobacter can also lead to higher infant mortality and growth stunting. In the Global Enterics Multicenter Study, where campylobacters were recovered from infant fecal samples obtained in Africa and south Asia, a novel Campylobacter, labeled Candidatus Campylobacter infans, was identified. This organism is related to Campylobacter fetus and Campylobacter hyointestinalis, which have also been recovered from human clinical samples. This study presents the complete chromosomal DNA sequence of the type strain for this novel Campylobacter, which was isolated from a patient with gastroenteritis in the Netherlands. This DNA sequence will permit the construction of enhanced typing methods that will detect this novel organism in human clinical samples.

Technical Abstract: Here we present the complete genome of a Campylobacter strain isolated in the Netherlands from a patient with gastroenteritis. The strain is identical to “Candidatus Campylobacter infans” recently recovered from metagenomic data as a novel Campylobacter species in breastfed infants with diarrheal disease in the Global Enterics Multicenter Study.