Bovine viral diarrhea virus: an updated ACVIM consensus statement with focus on virus biology, hosts, immunosuppression, and vaccination

Authors: WALZ, PAUL - Auburn University; CHAMORRO, MANUEL - Auburn University; Falkenberg, Shollie; PASSLER, THOMAS - Auburn University; VAN DER MEER, FRANK - University Of Calgary; WOOLUMS, AMELIA - Mississippi State University

Submitted to: Journal of Veterinary Internal Medicine
Publication Type: Review Article
Publication Acceptance Date: 5/11/2020
Publication Date: 7/7/2020
Citation: Walz, P.H., Chamorro, M.F., Falkenberg, S.M., Passler, T., Van Der Meer, F., Woolums, A. 2020. Bovine viral diarrhea virus: an updated ACVIM consensus statement with focus on virus biology, hosts, immunosuppression, and vaccination. Journal of Veterinary Internal Medicine. 34(5):1690-1706. https://doi.org/10.1111/jvim.15816.
DOI: https://doi.org/10.1111/jvim.15816

Interpretive Summary:

Technical Abstract: Control of bovine viral diarrhea virus (BVDV) in cattle populations across most of the world has remained elusive in spite of great advances in knowledge gained on this viral pathogen. A central and undeniable feature of virus perseverance in cattle herds is the unique mechanism of persistent infection. Managing BVDV involves controlling persistently infected carrier animals using a multidimensional approach involving vaccination, biosecurity, and identification of BVDV reservoirs. A decade has passed since the original ACVIM consensus statement on BVDV. While much has remained the same with respect to clinical signs of disease, pathogenesis of infection including persistent infection, and diagnosis, scientific articles published since 2010 have led to a greater understanding of difficulties associated with BVDV control. This consensus statement update on BVDV presents greater focus on topics currently relevant to the biology and control of this viral pathogen of cattle, including changes in virus subpopulations, infection in heterologous hosts, immunosuppression, and vaccination.