Low doses of eriocitrin attenuate metabolic impairment of glucose and lipids in ongoing obesogenic diet in mice

Authors: FERRIERA, PAULA - Universidade De Sao Paulo; Manthey, John; NERY, MARINA - Universidade De Sao Paulo; CESAR, THAIS - Universidade De Sao Paulo

Submitted to: American Chemical Society Abstracts
Publication Type: Abstract Only
Publication Acceptance Date: 10/18/2019
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Eriocitrin is a citrus flavonoid with a high capacity to reduce the oxidative stress related to metabolic disorders and obesity. We assessed the effects of low doses of eriocitrin in obese mice fed a high-fat diet. Fifty male C57BL/6J mice were randomly assigned into five groups of ten mice each. For obesity induction, mice were fed a high-fat diet (45% kcal from fat) for four weeks. At the end of this period, these mice started receiving the high-fat diet supplemented with eriocitrin at 10, 25 or 100 mg/kg body weight (bw) for an additional of four weeks. The control groups consisted of mice receiving a standard diet (10% kcal from fat) or the high-fat diet without supplement for eight consecutive weeks. At the end of the study mice supplemented with eriocitrin showed lower levels of blood serum triglycerides (10, 25 and 100 mg/kg bw) and glucose (25 mg/kg bw) and, improved levels of insulin (25 mg/kg bw), insulin resistance index (10 and 25 mg/kg bw), total-cholesterol (10, 25 and 100 mg/kg bw), resistin (10, 25 and 100 mg/kg bw), lipid peroxidation (25 and 100 mg/kg bw) and liver triglycerides (10, 25 and 100 mg/kg bw). In conclusion, the low doses of eriocitrin in the diet, specially the dose of 25 mg/kg bw, were capable to improve glucose and lipid metabolism dysregulation in an ongoing obesogenic environment.