Location: Dale Bumpers Small Farms Research CenterTitle: Copper oxide wire particles to complement control of gastrointestinal nematodes with levamisole and/or albendazole in lambs
|MILLER, JAMES - Louisiana State University|
|ACHARYA, MOHAN - University Of Arkansas|
Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 11/2/2020
Publication Date: 11/28/2020
Citation: Burke, J.M., Miller, J.E., Acharya, M., Wood, E.L. 2020. Copper oxide wire particles to complement control of gastrointestinal nematodes with levamisole and/or albendazole in lambs. Meeting Abstract. 98:73. https://doi.org/10.1093/jas/skz397.171.
Technical Abstract: Due to high prevalence of anthelmintic resistance (AR), complementary approaches to anthelmintic use to control gastrointestinal nematodes (GIN) in sheep are necessary. Copper oxide wire particles (COWP) are effective against Haemonchus contortus but not other GIN, and FAMACHA aids to minimize further development of AR. The objective was to determine the efficacy of COWP alone or in combination with levamisole, albendazole, or a 3-way combination to control GIN known to have AR to these anthelmintics. Naturally infected Katahdin lambs were selectively dewormed based on FAMACHA© and/or packed cell volume (PCV). If FAMACHA© scores were 3, 4, or 5, lambs received 1 g COWP alone (n = 120), COWP and levamisole (n = 47) or albendazole (n = 6), or a 3-way combination (n = 10), respectively. Untreated lambs were included (CON; n = 31). Feces and blood were collected on days 0 (day of deworming) and 14 for determination of fecal egg counts (FEC) and FEC reduction (FECRED) and PCV. Data were analyzed using repeated measures in a mixed model. The mean FECRED was greater than COWP alone when levamisole was included (P < 0.001). In a mixed GIN population, COWP in combination with levamisole increased the efficacy of H. contortus and other GIN genera present, offering greater GIN management in the presence of resistance to these anthelmintics.