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Title: New insights into the pathogenesis and treatment of malnutrition

Author
item THAXTON, GRACE - University Of Texas Medical Branch
item MELBY, PETER - University Of Texas Medical Branch
item MANARY, MARK - Children'S Nutrition Research Center (CNRC)
item PREIDIS, GEOFFREY - Baylor College Of Medicine

Submitted to: Gastroenterology Clinics of North America
Publication Type: Review Article
Publication Acceptance Date: 9/28/2018
Publication Date: 12/1/2018
Citation: Thaxton, G.E., Melby, P.C., Manary, M.J., Preidis, G.A. 2018. New insights into the pathogenesis and treatment of malnutrition. Gastroenterology Clinics of North America. 47(4):813-827. https://doi.org/10.1016/j.gtc.2018.07.007.
DOI: https://doi.org/10.1016/j.gtc.2018.07.007

Interpretive Summary:

Technical Abstract: The volume of research into the pathogenesis and treatment of malnutrition has increased markedly over the past ten years, providing mechanistic insights that can be leveraged into more effective treatment options. These discoveries have been driven by several landmark studies employing metabolomics, metagenomics, and new preclinical models. This review highlights some of the most important recent findings, focusing in particular on the emerging roles of prenatal and perinatal factors, protein deficiency, impaired gut barrier function, immune deficiency, and the intestinal microbiome.