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ARS Home » Southeast Area » Athens, Georgia » U.S. National Poultry Research Center » Exotic & Emerging Avian Viral Diseases Research » Research » Publications at this Location » Publication #362628

Research Project: Intervention Strategies to Predict, Prevent and Control Disease Outbreaks Caused by Emerging Strains of Virulent Newcastle Disease Viruses

Location: Exotic & Emerging Avian Viral Diseases Research

Title: First complete genome sequences of a subgenotype Vd Newcastle disease virus isolate

item GORAICHUK, IRYNA - Consultant
item MSOFFE, PETER - Sokoine University Of Agriculture
item CHIWANGAD, GASPAR - Tanzania Veterinary Laboratory Agency
item DIMITROV, KIRIL - Consultant
item Afonso, Claudio
item Suarez, David

Submitted to: Microbiology Resource Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 6/3/2019
Publication Date: 7/3/2019
Citation: Goraichuk, I.V., Msoffe, P.L., Chiwangad, G.H., Dimitrov, K.M., Afonso, C.L., Suarez, D.L. 2019. First complete genome sequences of a subgenotype Vd Newcastle disease virus isolate. Microbiology Resource Announcements. 8(27):e00436-19.

Interpretive Summary: Newcastle disease virus (NDV) is a deadly disease of poultry that is commonly found in Mexico, Central America, south America, Africa, and Asia. Some strains are more virulent than other strains, and it has become common to sequence NDV isolates as a way to characterize them. In an effort to characterize viruses from Tanzania, sequence analysis was performed on the complete genome of viruses. A unique virus was reported from Tanzania for the first time, genotype Vd, and this study provides the first complete genome sequence for this particular genotype of virus. The use of sequence information is valuable to help predict virulence of a virus and to understand how viruses move within and between countries. This type of information helps prepare the United States for future potential outbreaks.

Technical Abstract: A Newcastle disease virus was isolated from a chicken from a live birdmarket in the Mbeya region of Tanzania. Complete genome characterization of the isolate identified it as a member of subgenotype Vd. This is the first complete genome sequence of this subgenotype.