Location: Jean Mayer Human Nutrition Research Center On Aging
Title: A meta-analysis of vitamin K status and cardiovascular diseaseAuthor
SHEA, KYLA - Jean Mayer Human Nutrition Research Center On Aging At Tufts University | |
WEINER, DANIEL - Tufts Medical Center | |
MATUSZEK, GREGORY - Jean Mayer Human Nutrition Research Center On Aging At Tufts University | |
BOOTH, SARAH - Jean Mayer Human Nutrition Research Center On Aging At Tufts University | |
BARGER, KATHRYN - Jean Mayer Human Nutrition Research Center On Aging At Tufts University |
Submitted to: Current Developments in Nutrition
Publication Type: Abstract Only Publication Acceptance Date: 3/1/2019 Publication Date: 6/13/2019 Citation: Shea, K., Weiner, D.E., Matuszek, G.H., Booth, S.L., Barger, K. 2019. A meta-analysis of vitamin K status and cardiovascular disease. Current Developments in Nutrition. 3(Suppl_1). Abstract No. OR33-01-19. https://doi.org/10.1093%2Fcdn%2Fnzz039.OR33-01-19. DOI: https://doi.org/10.1093%2Fcdn%2Fnzz039.OR33-01-19 Interpretive Summary: Technical Abstract: Objective: Evidence suggests low vitamin K status may be associated with an increased cardiovascular disease (CVD) risk in people with CVD risk factors. The objective of this study was to summarize the association between vitamin K status and CVD, overall and according to baseline CVD risk, by conducting a participant-level meta-analysis using data from the Framingham Offspring Study, the Health, Aging, and Body Composition Study (Health ABC), and the Multi-ethnic Study of Atherosclerosis (MESA). Methods: Circulating phylloquinone (vitamin K1), measured from baseline fasting blood samples, was categorized as = 0.5 nM, >0.5 - = 1.0 nM and >1.0 nM. CVD was defined as confirmed ischemic heart disease, angina, resuscitated cardiac arrest, fatal or non-fatal myocardial infarction or stroke. Multivariable Cox proportional hazards models were used to evaluate the association between circulating phylloquinone and incident CVD overall and stratified according to baseline CVD risk factors. Results: Among the 3622 participants, (mean baseline age 65 (SD=11)65+/-11 yrs; 45% men, 65% white), there were 785 CVD events over a median of 13.0 years. Overall the risk for CVD did not differ significantly according to circulating phylloquinone categories [HR(95%CI) for CVD, compared to plasma phylloquinone >1.0 nM: =0.5 nM = 1.15 (0.96-1.38); >0.5 - = 1.0 nM = 0.99 (0.84-1.18)]. However, lower circulating phylloquinone was associated with higher incident CVD risk in those with diabetes, with a normal BMI, and in women (Table). Conclusion: Overall, circulating phylloquinone was not associated with CVD risk in community-dwelling adults. Although we detected an association between circulating phylloquinone and CVD among select subgroups, additional studies are needed to clarify if improving vitamin K status will benefit the cardiovascular health of certain segments of the population. |