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ARS Home » Northeast Area » Beltsville, Maryland (BARC) » Beltsville Agricultural Research Center » Animal Parasitic Diseases Laboratory » Research » Publications at this Location » Publication #360945

Research Project: Evaluation of Swine Immunity and Development of Novel Immune and Genomic Intervention Strategies to Prevent and/or Treat Respiratory Diseases of Swine

Location: Animal Parasitic Diseases Laboratory

Title: Annual Progress Report- National Research Support Project- NRSP-8 BARC station report

item Lunney, Joan

Submitted to: Experiment Station Bulletins
Publication Type: Experiment Station
Publication Acceptance Date: 2/15/2019
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: BARC has contributed to the National Animal Genome Research Program NRSP-8. The objectives are 1)Advance the status of reference genomes for all species, including basic annotation of worldwide genetic variation, by broad sequencing among different lines and breeds of animals; 2) Develop strategies to identify and exploit genes and allelic variation that contribute to economically relevant phenotypes and traits, in part through improving functional annotation of the genomes of our species; 3) Facilitate analysis, curation, storage, distribution and application of the enormous datasets now being generated by next-generation sequencing and related "omics" technologies with regard to animal species of agricultural interest. BARC has contributed to each objective. For Objective 1: Update annotation and nomenclature for swine major histocompatibility complex (MHC) or swine leukocyte antigen (SLA) complex. For Objective 2: Use SNP chips and transcriptomic analyses to map disease and immune traits as part of the porcine reproductive and respiratory syndrome (PRRS) Host Genomic Consortium (PHGC); Integrate genomic, transcriptional, and proteomic approaches for improved understanding of biological mechanisms underlying anti-viral disease and immune response traits; and Use targeted transcriptomic analyses to assess fetal pig responses to reproductive PRRSV infection; For Objective 3: The PRRS Host Genomic Consortium database (PHGCdb) has continued to be used to warehouse detailed phenotypes and genotypes of pigs in PHGC trials; and Update nomenclature and website for swine major histocompatibility complex (MHC) or swine leukocyte antigen (SLA) complex. This information will serve as a basis for determining critical effects of pig genetics on control of infectious disease and vaccine responses.