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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #360737

Research Project: Sarcopenia, Nutrition, and Physical Activity

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: a systematic review and meta-analysis

Author
item Custodero, Carlo - University Of Florida
item Mankowski, Robert - University Of Florida
item Lee, Stephanie - University Of Florida
item Chen, Zhiguo - University Of Florida
item Wu, Samuel Shangwu - University Of Florida
item Manini, Todd - University Of Florida
item Hincapie Echeverri, Jacobo - University Of Florida
item Sabba, Carlo - University Of Bari
item Beavers, Daniel - Wake Forest University
item Cauley, Jane - University Of Pittsburgh
item Espeland, Mark - Wake Forest University
item Fielding, Roger - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item Kritchevsky, Stephen - Wake Forest University
item Liu, Christine - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item Mcdermott, Mary - Northwestern University
item Miller, Michael - Wake Forest University
item Tracy, Russell - University Of Vermont
item Newman, Anne - University Of Pittsburgh
item Ambrosius, Walter - Wake Forest University
item Pahor, Marco - University Of Florida
item Anton, Steve - University Of Florida

Submitted to: Ageing Research Reviews
Publication Type: Review Article
Publication Acceptance Date: 5/21/2018
Publication Date: 5/25/2018
Citation: Custodero, C., Mankowski, R.T., Lee, S.A., Chen, Z., Wu, S., Manini, T.M., Hincapie Echeverri, J., Sabba, C., Beavers, D.P., Cauley, J.A., Espeland, M.A., Fielding, R.A., Kritchevsky, S.B., Liu, C.K., Mcdermott, M.M., Miller, M.E., Tracy, R.P., Newman, A.B., Ambrosius, W.T., Pahor, M., Anton, S.D. 2018. Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: a systematic review and meta-analysis. Ageing Research Reviews. 46:42-59. https://doi.org/10.1016/j.arr.2018.05.004.
DOI: https://doi.org/10.1016/j.arr.2018.05.004

Interpretive Summary:

Technical Abstract: Growing evidence suggests chronic low-grade inflammation (LGI) as a possible mechanism underlying the aging process. Some biological and pharmaceutical compounds may reduce systemic inflammation and potentially avert functional decline occurring with aging. The aim of the present meta-analysis was to examine the association of pre-selected interventions on two established biomarkers of inflammation, interleukin-6 (IL-6), and C-reactive protein (CRP) in middle-age and older adults with chronic LGI. We reviewed the literature on potential anti-inflammatory compounds, selecting them based on safety, tolerability, acceptability, innovation, affordability, and evidence from randomized controlled trials. Six compounds met all five inclusion criteria for our systematic review and meta-analysis: angiotensin II receptor blockers (ARBs), metformin, omega-3, probiotics, resveratrol and vitamin D. We searched in MEDLINE, PubMed and EMBASE database until January 2017. A total of 49 articles fulfilled the selection criteria. Effect size of each study and pooled effect size for each compound were measured by the standardized mean difference. I2 was computed to measure heterogeneity of effects across studies. The following compounds showed a significant small to large effect in reducing IL-6 levels: probiotics (-0.68 pg/ml), ARBs (-0.37 pg/ml) and omega-3 (-0.19 pg/ml). For CRP, a significant small to medium effect was observed with probiotics (-0.43 mg/L), ARBs (-0.2 mg/L), omega-3 (-0.17 mg/L) and metformin (-0.16 mg/L). Resveratrol and vitamin D were not associated with any significant reductions in either biomarker. These results suggest that nutritional and pharmaceutical compounds can significantly reduce established biomarkers of systemic inflammation in middle-age and older adults. The findings should be interpreted with caution, however, due to the evidence of heterogeneity across the studies.