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ARS Home » Pacific West Area » Davis, California » Western Human Nutrition Research Center » Obesity and Metabolism Research » Research » Publications at this Location » Publication #360673
Title: A Mediterranean-style eating pattern lower in lean red meat reduced plasma trimethylamine N-oxide in adults classified as overweight or obese

Author
item Gertz, Erik
item WANG, YU - Purdue University
item O'CONNOR, LAUREN - Purdue University
item CAMPBELL, WAYNE - Purdue University
item Bennett, Brian

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 6/20/2019
Publication Date: 10/24/2019
Citation: Gertz, E.R., Wang, Y., O'Connor, L., Campbell, W.W., Bennett, B.J. 2019. A Mediterranean-style eating pattern lower in lean red meat reduced plasma trimethylamine N-oxide in adults classified as overweight or obese. Meeting Abstract. 3(1). https://doi.org/10.1093/cdn/nzz044.P08-030-19.
DOI: https://doi.org/10.1093/cdn/nzz044.P08-030-19

Interpretive Summary:

Technical Abstract: Objective: To determine whether the addition of lean red meat to a Mediterranean style diet alters the plasma concentrations of Trimethylamine N-Oxide (TMAO) in middle-aged overweight or obese adults who are at risk for cardiometabolic disease (CMD). Methods: A total of 39 subjects in a randomized, crossover and controlled feeding trial were assigned to a Mediterranean style diet for two 5 week interventions separated by 4 week of self-selected eating washout. The Mediterranean style diets contained ~500 g (Med-Red) or ~200 g (Med-Control) of lean, unprocessed beef or pork per week. Plasma samples were collected at baseline and post intervention time points and TMAO was measured by stable isotope dilution chromatography tandem mass spectrometry. Geometric means were compared with mixed model tests in SAS. Results: Post-diet plasma TMAO concentrations were found to be significantly lower in the Med-control group compared to the Med-Red group (3.1'1.2 and 5.0'2.6 'M, respectively, intervention X time= 0.0025). Pre-diet values for both groups were not significantly different from each other (5.2'4.5 and 4.4'2.7 'M, respectively, p = 0.48) and there was a significant change over time in the Med-control group but not the Med-Red group (p=0.0040 and 0.26 respectively). Conclusion: A Mediterranean style diet that is lower in lean unprocessed red meat reduced plasma TMAO in middle-aged overweight or obese adults. Despite the decrease in concentration, both diet interventions are in the low single digit concentration range which is similar to what has been reported by other research groups in healthy adults. The clinical effects on ardiometabolic disease remain to be determined. This trial was registered at clinicaltrials.gov as NCT02573129. Supported by the Beef Checkoff, the Pork Checkoff, the National Institute of Health’s Ingestive Behavior Research Center at Purdue University (5T32DK076540-08), the National Institute of Health’s Indiana Clinical and Translational Sciences Institute and the USDA-ARS-Western Human Nutrition Research Center.