Location: Virus and Prion ResearchTitle: Evolution of influenza A virus in swine and vaccine selection Author
|Anderson, T - Oak Ridge Institute For Science And Education (ORISE)|
|Chang, Jennifer - Oak Ridge Institute For Science And Education (ORISE)|
Submitted to: Iowa Veterinary Medical Association
Publication Type: Proceedings
Publication Acceptance Date: 1/31/2019
Publication Date: N/A
Technical Abstract: Although IAV in swine has been studied for nearly a century, many questions remain unanswered. A USDA IAV surveillance system was implemented in 2009 and has greatly increased the knowledge of IAV circulating in U.S. herds. Surveillance, epidemiologic investigations, and genetic characterization of IAV associated with respiratory disease outbreaks in pigs are necessary to monitor the evolution of viruses in the pig population. Additionally, antigenic characterization is needed to fully understand the relevance of genetic changes for vaccine antigen selection, and vaccine efficacy must be evaluated in the context of serologic cross-reactivity when new variants arise. A cycle of human-to-swine transmission, followed by evolution in swine, then re-entry into the human population has been demonstrated in contemporary human and swine IAV. The bi-directional interspecies transmission of IAV and ongoing evolution of these viruses in swine and humans is unprecedented in the history of this virus. Recent advances in regional surveillance programs, sequencing methodologies, research, and collaboration through networks have established a framework upon which to continue efforts to control this important virus in swine through production practices and/or improved vaccines.