|STICE, CAMILLA - Jean Mayer Human Nutrition Research Center On Aging At Tufts University|
|XIA, HUI - Jean Mayer Human Nutrition Research Center On Aging At Tufts University|
|WANG, XIANG-DONG - Jean Mayer Human Nutrition Research Center On Aging At Tufts University|
Submitted to: Chronic Diseases and Translational Medicine
Publication Type: Review Article
Publication Acceptance Date: 9/28/2018
Publication Date: 12/18/2018
Citation: Stice, C.P., Xia, H., Wang, X. 2018. Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development. Chronic Diseases and Translational Medicine. https://doi.org/10.1016/j.cdtm.2018.11.001.
Technical Abstract: Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. The incidence of hepatocellular carcinoma (HCC) is increasing in the United States, and chronic, excessive alcohol consumption is responsible for 32-45% of all the liver cancer cases in the United States. The addictive power of alcohol is strong, 1 out of every 12 Americans is an alcoholic. The association between alcohol consumption, ALD, and HCC has been well established. Possible mechanisms of alcohol-induced HCC include the acetaldehyde as a carcinogen, induction of cytochrome P4502E1 (CYP2E1), induction of oxidative stress and inflammation, and interfering with retinoid signaling pathway. Avoidance of chronic or excessive alcohol intake is the best protection against alcohol-related liver injury; however, the social presence and addictive power of alcohol are strong. Therefore, mechanistic studies are essential and dietary intervention represents a promising disease control strategy for the prevention of ALD and HCC. The review will focus on the molecular mechanisms by which excessive alcohol initiates ALD and promotes HCC and prevention of these hepatic injuries through dietary tomato and lycopene intervention. Our findings support whole food as an effective disease prevention strategy and highlight the dangerous interactions between alcohol consumption and supplementation with purified compounds.