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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #358924

Research Project: Nutrients, Aging, and Musculoskeletal Function

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Vitamin D supplementation in patients with type 2 diabetes: the vitamin D for established type 2 diabetes (DDM2) study

Author
item ANGELLOTTI, EDITH - Tufts Medical Center
item D'ALESSIO, DAVID - Duke University
item DAWSON-HUGHES, BESS - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item NELSON, JASON - Tufts Medical Center
item COHEN, ROBERT - University Of Cincinnati
item GASTALDELLI, AMALIA - National Research Council - Italy
item PITTAS, ANASTASSIOS - Tufts Medical Center

Submitted to: Journal of the Endocrine Society
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 2/21/2018
Publication Date: 2/26/2018
Citation: Angellotti, E., D'Alessio, D., Dawson-Hughes, B., Nelson, J., Cohen, R., Gastaldelli, A., Pittas, A.G. 2018. Vitamin D supplementation in patients with type 2 diabetes: the vitamin D for established type 2 diabetes (DDM2) study. Journal of the Endocrine Society. 2(4):310-321. https://doi.org/10.1210/js.2018-00015.
DOI: https://doi.org/10.1210/js.2018-00015

Interpretive Summary: Although type 2 diabetes is effectively treated with pharmacotherapy, such treatment is associated with poor long-term adherence, potential side effects, and high costs. Therefore, identification of alternative therapeutic options that can be applied at the public health level are needed to decrease diabetes-related burden and costs. Observational data support a role for vitamin D in type 2 diabetes, but evidence from trials is inconclusive. The aim of this study was to evaluate the effectiveness of oral daily vitamin D supplementation on pancreatic insulin-producing cells and blood sugar levels in 127 adults with well-controlled type 2 diabetes. Participants were randomly assigned to treatment with 4,000 IU per day of vitamin D or placebo for 48 weeks. The serum concentration of 25-hydroxyvitamin D increased in the supplemented group; however, vitamin D supplementation had no effect on insulin sensitivity or blood sugar levels. Vitamin D supplementation over 1 year does not appear to make a difference in adults with well-controlled type 2 diabetes.

Technical Abstract: Context: Observational data support a role for vitamin D in type 2 diabetes but evidence from trials is inconclusive. Objective: To evaluate the effect of oral daily vitamin D supplementation on beta cell function and Hemoglobin A1c (HbA1c) in patients with well-controlled type 2 diabetes. Design: Double-blind, randomized, placebo-controlled clinical trial. Setting: Tufts Medical Center, Boston, MA; VA Medical Center, Cincinnati, OH. Participants: 127 patients (mean age 60 years) with stable (HbA1c