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ARS Home » Pacific West Area » Albany, California » Western Regional Research Center » Produce Safety and Microbiology Research » Research » Publications at this Location » Publication #354510

Research Project: Molecular Identification and Characterization of Bacterial and Viral Pathogens Associated with Foods

Location: Produce Safety and Microbiology Research

Title: Complete genome sequence of Acinetobacter radioresistens strain LH6, a multidrug-resistant phage-propagating strain

Author
item Crippen, Clay - University Of Georgia
item Huynh, Steven
item Miller, William - Bill
item Parker, Craig
item Szymanski, Christine - University Of Georgia

Submitted to: Microbiology Resource Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 7/15/2018
Publication Date: 8/9/2018
Citation: Crippen, C., Huynh, S., Miller, W.G., Parker, C., Szymanski, C.M. 2018. Complete genome sequence of Acinetobacter radioresistens strain LH6, a multidrug-resistant phage-propagating strain. MICROBIOLOGY RESOURCE ANNOUNCEMENTS. 7(5):e00929-18. https://doi.org/10.1128/MRA.00929-18.
DOI: https://doi.org/10.1128/MRA.00929-18

Interpretive Summary: Antibiotic resistance has been increasing at alarming rates both in hospitals and community settings. Infection with Acinetobacter baumannii is considered a significant threat to human health due to its survival mechanisms and ability to acquire a broad range of antibiotic resistance genes. However, less is known about the role of nonpathogenic Acinetobacter species, which have similar abilities to acquire antimicrobial resistance determinants, and are remarkably robust, suggesting they may play a major role in the acquisition and spread of drug resistance determinants among Acinetobacter. We report here the genome sequence of a recently-isolated, poultry-commensal Acinetobacter radioresistens strain. Analysis indicates that this strain encodes many proteins associated with virulence and persistence. Additionally, several multidrug efflux systems and other genes relevant to antimicrobial resistance were identified. All these features indicate that this strain is multi-drug resistant, environmentally-resilient and capable of multiple mechanisms of genetic exchange, making it an ideal reservoir species for the spread of antimicrobial resistance.

Technical Abstract: Antimicrobial resistance is a major problem worldwide. Understanding the interplay between drug resistant pathogens such as Acinetobacter baumannii and related species, potentially acting as environmental reservoirs, is critical for preventing the spread of resistance determinants. Here we report the genome sequence of a multidrug-resistant phage-propagating strain of Acinetobacter radioresistens.