|Santanasto, Adam - University Of Pittsburgh|
|Glynn, Nancy - University Of Pittsburgh|
|Lovato, Laura - Wake Forest University|
|Blair, Steven - University Of South Carolina|
|Fielding, Roger - Jean Mayer Human Nutrition Research Center On Aging At Tufts University|
|Gill, Thomas - Yale University|
|Guralnik, Jack - University Of Maryland|
|Hsu, Fang-chi - Wake Forest University|
|King, Abby - Stanford University|
|Strotmeyer, Elsa - University Of Pittsburgh|
|Manini, Todd - University Of Florida|
|March, Anthony - Wake Forest University|
|Mcdermott, Mary - Northwestern University|
|Goodpaster, Bret - Sanford And Burnham Medical Research Institute|
|Pahor, Marco - University Of Florida|
|Newman, Anne - University Of Pittsburgh|
Submitted to: Journal of American Geriatric Society
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 2/21/2017
Publication Date: 7/12/2017
Citation: Santanasto, A.J., Glynn, N.W., Lovato, L.C., Blair, S.N., Fielding, R.A., Gill, T.M., Guralnik, J.M., Hsu, F., King, A.C., Strotmeyer, E.S., Manini, T.M., March, A.P., McDermott, M.M., Goodpaster, B.H., Pahor, M., Newman, A.B. 2017. Effect of physical activity versus health education on physical function, grip strength and mobility. Journal of American Geriatric Society. 65(7):1427-1433. https://doi.org/10.1111/jgs.14804.
DOI: https://doi.org/10.1111/jgs.14804 Interpretive Summary: We examined the effects of a structured physical activity program (PA) compared to a health education control group (HE) on measures of physical function (walking, chair rising, standing balance) in 1,635 adults at risk for mobility disability who were approximately 78 years of age and 67.2% women. Physical function (Short Physical Performance Battery score [a composite measure of walking, chair rising, and standing balance]) was higher in PA versus HE across all follow-up times. The difference in Short Physical Performance Battery scores between groups was primarily attributable to the repeated chair-rise component. In addition, 400 m walking speed was faster in PA versus HE group. These results confirm that structured physical activity can improve physical functioning in older adults at risk for disability.
Technical Abstract: Background: Physical activity (PA) reduces the rate of mobility disability, compared with health education (HE), in at risk older adults. It is important to understand aspects of performance contributing to this benefit. Objective: To evaluate intervention effects on tertiary physical performance outcomes. Design: The Lifestyle Interventions and Independence for Elders (LIFE) was a multi-centered, single-blind randomized trial of older adults. Setting: Eight field centers throughout the United States. Participants: 1635 adults aged 78.9 +/- 5.2 years, 67.2% women at risk for mobility disability (Short Physical Performance Battery [SPPB] <10). Interventions: Moderate PA including walking, resistance and balance training compared with HE consisting of topics relevant to older adults. Outcomes: Grip strength, SPPB score and its components (balance, 4 m gait speed, and chair-stands), as well as 400 m walking speed. Results: Total SPPB score was higher in PA versus HE across all follow-up times (overall P = .04) as was the chair-stand component (overall P < .001). No intervention effects were observed for balance (overall P = .12), 4 m gait speed (overall P = .78), or grip strength (overall P = .62). However, 400 m walking speed was faster in PA versus HE group (overall P =<.001). In separate models, 29% of the rate reduction of major mobility disability in the PA versus HE group was explained by change in SPPB score, while 39% was explained by change in the chair stand component. Conclusion: Lower extremity performance (SPPB) was significantly higher in the PA compared with HE group. Changes in chair-stand score explained a considerable portion of the effect of PA on the reduction of major mobility disability-consistent with the idea that preserving muscle strength/power may be important for the prevention of major mobility disability.