|HASLAM, DANIELLE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University|
|MCKEOWN, NICOLA - Jean Mayer Human Nutrition Research Center On Aging At Tufts University|
|HERMAN, MARK - Duke University|
|LICHTENSTEIN, ALICE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University|
|DASHTI, HASSAN - Massachusetts General Hospital|
Submitted to: Frontiers in Endocrinology
Publication Type: Review Article
Publication Acceptance Date: 12/15/2017
Publication Date: 1/8/2018
Citation: Haslam, D., McKeown, N.M., Herman, M.A., Lichtenstein, A.H., Dashti, H.S. 2018. Interactions between genetics and sugar-sweetened beverage consumption on health outcomes: a review of gene-diet interaction studies. Frontiers in Endocrinology. 8:368. https://doi.org/10.3389/fendo.2017.00368.
Technical Abstract: The consumption of sugar-sweetened beverages (SSB), which includes soft drinks, fruit drinks, and other energy drinks, is associated with excess energy intake and increased risk for chronic metabolic disease among children and adults. Thus, reducing SSB consumption is an important strategy to prevent the onset of chronic diseases, and achieve and maintain a healthy body weight. The mechanisms by which excessive SSB consumption may contribute to complex chronic diseases may partially depend on an individual's genetic predisposition. Gene-SSB interaction investigations, either limited to single genetic loci or including multiple genetic variants, aim to use genomic information to define mechanistic pathways linking added sugar consumption from SSBs to those complex diseases. The purpose of this review is to summarize the available gene-SSB interaction studies investigating the relationships between genetics, SSB consumption, and various health outcomes. Current evidence suggests there are genetic predispositions for an association between SSB intake and adiposity; evidence for a genetic predisposition between SSB and type 2 diabetes or cardiovascular disease is limited.