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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #352342

Research Project: Sarcopenia, Nutrition, and Physical Activity

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Dynapenia and metabolic health in obese and nonobese adults aged 70 years and older: The LIFE Study

Author
item Aubertin-leheudre, Mylene - University Of Florida
item Anton, Stephen - University Of Florida
item Beavers, Daniel - Wake Forest University
item Manini, Todd - University Of Florida
item Fielding, Roger - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item Newman, Ann - University Of Pittsburgh
item Church, Tim - Pennington Biomedical Research Center
item Kritchevsky, Stephen - Wake Forest University
item Conroy, David - Pennsylvania State University
item Mcdermott, Mary - Northwestern University
item Botoseneanu, Anda - University Of Michigan
item Hauser, Michelle - Stanford University
item Pahor, Marco - University Of Florida

Submitted to: Journal of the American Medical Directors Association - Post-Acute and Long Term Care Medicine
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 3/1/2016
Publication Date: 4/1/2017
Citation: Aubertin-Leheudre, M., Anton, S.D., Beavers, D.P., Manini, T.M., Fielding, R.A., Newman, A., Church, T., Kritchevsky, S.B., Conroy, D., McDermott, M.M., Botoseneanu, A., Hauser, M.E., Pahor, M. 2017. Dynapenia and metabolic health in obese and nonobese adults aged 70 years and older: The LIFE Study. Journal of the American Medical Directors Association - Post-Acute and Long Term Care Medicine. 18(4):312-319.

Interpretive Summary: The purpose of this study was to examine the relationship between muscle weakness and metabolic risk factors in obese and non-obese older adults. We examined a total of 1,453 men and women (age >/= 70 years) from the Lifestyle Interventions and Independence for Elders (LIFE) Study. We found that older adults who were weak yet not obese had fewer metabolic disease risk factors than older adults who were neither obese nor weak. Moreover, among obese older adults, weakness was associated with lower risk of a high waist circumference and elevated diastolic blood pressure. Additionally, the presence of muscle weakness did not increase cardiometabolic disease risk in either obese or non-obese older adults.

Technical Abstract: OBJECTIVE: The purpose of this study was to examine the relationship between dynapenia and metabolic risk factors in obese and nonobese older adults. METHODS: A total of 1453 men and women (age >/= 70 years) from the Lifestyle Interventions and Independence for Elders (LIFE) Study were categorized as (1) nondynapenic/nonobese (NDYN-NO), (2) dynapenic/nonobese (DYN-NO), (3) nondynapenic/obese (NDYN-O), or (4) dynapenic/obese (DYN-O), based on muscle strength (Foundation for the National Institute of Health criteria) and body mass index. Dependent variables were blood lipids, fasting glucose, blood pressure, presence of at least 3 metabolic syndrome (MetS) criteria, and other chronic conditions. RESULTS: A significantly higher likelihood of having abdominal obesity criteria in NDYN-NO compared with DYN-NO groups (55.6 vs 45.1%, P </= .01) was observed. Waist circumference also was significantly higher in obese groups (DYN-O = 114.0 +/- 12.9 and NDYN-O = 111.2 +/- 13.1) than in nonobese (NDYN-NO = 93.1 +/- 10.7 and DYN-NO = 92.2 +/- 11.2, P </= .01); and higher in NDYN-O compared with DYN-O (P = .008). Additionally, NDYN-O demonstrated higher diastolic blood pressure compared with DYN-O (70.9 +/- 10.1 vs 67.7 +/- 9.7, P </= .001). No significant differences were found across dynapenia and obesity status for all other metabolic components (P > .05). The odds of having MetS or its individual components were similar in obese and nonobese, combined or not with dynapenia (nonsignificant odds ratio [95% confidence interval]). CONCLUSION: Nonobese dynapenic older adults had fewer metabolic disease risk factors than nonobese and nondynapenic older adults. Moreover, among obese older adults, dynapenia was associated with lower risk of meeting MetS criteria for waist circumference and diastolic blood pressure. Additionally, the presence of dynapenia did not increase cardiometabolic disease risk in either obese or nonobese older adults.