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ARS Home » Southeast Area » Athens, Georgia » U.S. National Poultry Research Center » Egg Safety & Quality Research » Research » Publications at this Location » Publication #350330

Research Project: Reduction of Invasive Salmonella enterica in Poultry through Genomics, Phenomics and Field Investigations of Small Multi-Species Farm Environments

Location: Egg Safety & Quality Research

Title: Complete Genome Sequence of a Ciprofloxacin-Resistant Salmonella enterica subsp. enterica Serovar Kentucky Sequence Type 198 Strain, PU131, Isolated from a Human Patient in Washington State.

item SHAH, DEVENDRA - Washington State University
item PAUL, NARAYAN - Washington State University
item Guard, Jean

Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 2/8/2018
Publication Date: 3/1/2018
Citation: Shah, D.H., Paul, N.C., Guard, J.Y. 2018. Complete genome sequence of a ciprofloxacin resistant Salmonella enterica subsp. enterica serovar Kentucky sequence of a ciprofloxacin strain, PU131, isolated from a human patient in Washington State. Genome Announcements. 6(9):e00125-18.

Interpretive Summary: Salmonella enterica serotype Kentucky is frequently isolated from the poultry environment. While it is not often a direct cause of foodborne illness, it is nonetheless an emerging pathogen in humans because it harbors antibiotic resistance genes. It is most often acquired by people following hospitalization and international travel. Whole genome sequencing was performed to characterize ciprofloxacin resistant serotype S. Kentucky ST198 strain PU131, which was isolated from a person and also reported in dairy cattle in the USA. A combination of 3 genes, two in gyrA and one in parC, suggests high-level fluoroquinolone resistance. The complete sequence will aid in developing improved detection/subtyping methods for epidemiological source tracking and to a better understanding of the pathogenicity and antimicrobial resistance of this emerging pathogen.

Technical Abstract: A ciprofloxacin resistant (CipR) Salmonella enterica subsp. enterica serovar Kentucky ST198 has rapidly and extensively disseminated globally to become a major food-safety and public health concern. Here, we report a complete genome sequence of a CipR S. Kentucky ST198 strain PU131 isolated from a human patient in Washington (USA).