Location: Children's Nutrition Research CenterTitle: Diet-induced inflammation and mammary ductal development: Alternative activation of estrogen-dependent stromal-epithelial signaling
|HADSELL, DARRYL - Children'S Nutrition Research Center (CNRC)|
Submitted to: Endocrinology
Publication Type: Other
Publication Acceptance Date: 6/14/2017
Publication Date: 10/1/2017
Citation: Hadsell, D.L. 2017. Diet-induced inflammation and mammary ductal development: Alternative activation of estrogen-dependent stromal-epithelial signaling. Endocrinology. 158(10):3088-3089.
Technical Abstract: The mechanisms controlling allometric development of the mammary ductal tree have largely been defined through key studies in rodent model systems. The development of this system is known to depend on the integrated actions of pituitary and ovarian hormones, locally produced growth factors, extracellular matrix proteins, and proteases. It has also become clear that this process involves a finely orchestrated set of communications between numerous cells types. These include subclasses of ductal epithelial cells, along with stromal fibroblasts, adipocytes, and cells of the innate immune system.