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ARS Home » Northeast Area » Leetown, West Virginia » Cool and Cold Water Aquaculture Research » Research » Publications at this Location » Publication #349123

Research Project: Integrated Research Approaches for Improving Production Efficiency in Salmonids

Location: Cool and Cold Water Aquaculture Research

Title: Physiological and molecular mechanisms of methionine restriction

item LATIMER, MARY - University Of Alabama
item FREIJ, KHALID - University Of Alabama
item Cleveland, Beth
item BIGA, PEGGY - University Of Alabama

Submitted to: Frontiers in Endocrinology
Publication Type: Review Article
Publication Acceptance Date: 4/17/2018
Publication Date: 5/4/2018
Citation: Latimer, M., Freij, K., Cleveland, B.M., Biga, P. 2018. Physiological and molecular mechanisms of methionine restriction. Frontiers in Endocrinology. 9:217.

Interpretive Summary:

Technical Abstract: The activation of miRNAs during methionine restriction (MR) provides a potential link between changes in methylation and the integrated stress responses in cells. Studies utilizing rainbow trout myosatellite cells in vitro and in vivo, have shown that methionine can regulate the level of expression of miRNAs. This review explores mechanisms responsible for the MR phenotype including miRNA's, amino acid starvation, and stress response pathways. Future research should investigate miRNAs in circulation during MR. MicroRNAs found to be altered during MR can then be analyzed for their role in controlling muscle-specific transcription factors like MyoD and myogenin. Identified miRNAs can also be explored in other tissues to observe conservation of function during stress responses in tissue.