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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #348510

Research Project: Genomics, Nutrition, and Health

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Environmental chemicals and DNA methylation in adults: a systematic review of the epidemiologic evidence

Author
item Ruiz-hernandez, Adrian - University Clinical Hospital Of Valencia
item Kuo, Chin-chi - Johns Hopkins University
item Rentero-garrido, Pilar - Incliva Biomedical Research Institute
item Tang, Wan-yee - Johns Hopkins University
item Redon, Josep - University Clinical Hospital Of Valencia
item Ordovas, Jose - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item Navas-acien, Ana - Johns Hopkins University
item Tellez-plasza, Maria - Johns Hopkins University

Submitted to: Journal of Clinical Epigenetics
Publication Type: Review Article
Publication Acceptance Date: 2/9/2015
Publication Date: 4/29/2015
Citation: Ruiz-Hernandez, A., Kuo, C., Rentero-Garrido, P., Tang, W., Redon, J., Ordovas, J.M., Navas-Acien, A., Tellez-Plasza, M. 2015. Environmental chemicals and DNA methylation in adults: a systematic review of the epidemiologic evidence. Journal of Clinical Epigenetics. 7:55. https://doi.org/10.1186/s13148-015-0055-7.

Interpretive Summary:

Technical Abstract: Current evidence supports the notion that environmental exposures are associated with DNA-methylation and expression changes that can impact human health. Our objective was to conduct a systematic review of epidemiologic studies evaluating the association between environmental chemicals with DNA methylation levels in adults. After excluding arsenic, recently evaluated in a systematic review, we identified a total of 17 articles (6 on cadmium, 4 on lead, 2 on mercury, 1 on nickel, 1 on antimony, 1 on tungsten, 5 on persistent organic pollutants and perfluorinated compounds, 1 on bisphenol A, and 3 on polycyclic aromatic hydrocarbons). The selected articles reported quantitative methods to determine DNA methylation including immunocolorimetric assays for total content of genomic DNA methylation, and microarray technologies, methylation-specific quantitative PCR, Luminometric Methylation Assay (LUMA), and bisulfite pyrosequencing for DNA methylation content of genomic sites such as gene promoters, LINE-1, Alu elements, and others. Considering consistency, temporality, strength, dose-response relationship, and biological plausibility, we concluded that the current evidence is not sufficient to provide inference because differences across studies and limited samples sizes make it difficult to compare across studies and to evaluate sources of heterogeneity. Important questions for future research include the need for larger and longitudinal studies, the validation of findings, and the systematic evaluation of the dose-response relationships. Future studies should also consider the evaluation of epigenetic marks recently in the research spotlight such as DNA hydroxymethylation and the role of underlying genetic variants.