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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #348045

Research Project: Sarcopenia, Nutrition, and Physical Activity

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Effect of structured physical activity and nutritional supplementation on physical function in mobility-limited older adults: results from the VIVE2 randomized trial

Author
item Fielding, Roger - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item Travison, Thomas - Hebrew Senior Life
item Kirn, Dylan - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item Koochek, Afsaneh - Uppsala University
item Reid, Kieran - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item Von Berens, Asa - Uppsala University
item Zhu, Hao - Hebrew Senior Life
item Folta, Sara - Friedman School At Tufts
item Sachek, Jannifer - Friedman School At Tufts
item Nelson, Miriam - University Of New Hampshire
item Liu, Christine - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item Aberg, Anna - Uppsala University
item Nydahl, Margaretha - Uppsala University
item Lilja, Mats - Karolinska Institute
item Gustafsson, Thomas - Karolinska Institute
item Cederholm, Tommy - Uppsala University

Submitted to: Journal of Nutrition Health and Aging
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 5/3/2017
Publication Date: 6/3/2017
Citation: Fielding, R.A., Travison, T.G., Kirn, D.R., Koochek, A., Reid, K.F., Von Berens, A., Zhu, H., Folta, S.C., Sachek, J.M., Nelson, M.E., Liu, C., Aberg, A.C., Nydahl, M., Lilja, M., Gustafsson, T., Cederholm, T. 2017. Effect of structured physical activity and nutritional supplementation on physical function in mobility-limited older adults: results from the VIVE2 randomized trial. Journal of Nutrition Health and Aging. 21(9):936-942. https://doi.org/10.1007/s12603-017-0936-x.

Interpretive Summary: The interactions between nutritional supplementation and regular participation in exercise training on changes in physical function among older adults remain unclear. The primary objective of this study was to examine the impact of nutritional supplementation plus structured exercise training on 400M walk capacity in mobility-limited older adults across two sites (Boston, USA and Stockholm, Sweden). Older men and women were randomly assigned to a six month long structured exercise program (3 per week) with a daily nutritional supplement (150kcal, 20g whey protein, 800 IU vitamin D) or placebo (30kcal, non-nutritive). Both groups experienced a statistically significant and clinically meaningful improvement in 400 M walk speed. However, there was no difference in 400 M walk improvement between the group that received the nutritional supplement and the group that received the placebo. These results suggest that regular exercise can improve walking speed with no added benefit of nutritional supplementation.

Technical Abstract: Objectives: The interactions between nutritional supplementation and physical activity on changes in physical function among older adults remain unclear. The primary objective of this study was to examine the impact of nutritional supplementation plus structured physical activity on 400M walk capacity in mobility-limited older adults across two sites (Boston, USA and Stockholm, Sweden). Design: All subjects participated in a physical activity program (3x/week for 24 weeks), involving walking, strength, balance, and flexibility exercises. Subjects were randomized to a daily nutritional supplement (150kcal, 20g whey protein, 800 IU vitamin D) or placebo (30kcal, non-nutritive). Setting: Participants were recruited from urban communities at 2 field centers in Boston MA USA and Stockholm SWE. Participants: Mobility-limited (Short Physical Performance Battery (SPPB) </=9) and vitamin D insufficient (serum 25(OH)D 9-24 ng/ml) older adults were recruited for this study. Measurements: Primary outcome was gait speed assessed by the 400M walk. Results: 149 subjects were randomized into the study (mean age= 77.5 +/- 5.4; female= 46.3%; mean SPPB= 7.9 +/-1.2; mean 25(OH)D= 18.7 +/- 6.4 ng/ml). Adherence across supplement and placebo groups was similar (86% and 88%, respectively), and was also similar across groups for the physical activity intervention (75% and 72%, respectively). Both groups demonstrated an improvement in gait speed with no significant difference between those who received the nutritional supplement compared to the placebo (0.071 and 0.108 m/s, respectively (p=0.06)). Similar effects in physical function were observed using the SPPB. Serum 25(OH)D increased in supplemented group compared to placebo 7.4 ng/ml versus 1.3 ng/ml respectively. Conclusion: Results suggest improved gait speed following physical activity program with no further improvement with added nutritional supplementation.