|Rosenberg, Irwin - Jean Mayer Human Nutrition Research Center On Aging At Tufts University|
|Selhub, Jacob - Jean Mayer Human Nutrition Research Center On Aging At Tufts University|
Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 5/20/2017
Publication Date: 6/20/2018
Citation: Rosenberg, I.H., Selhub, J. 2018. Assessing all the Evidence for Risks and Benefits With Folic Acid Fortification and Supplementation. In: Mannar, V.M.G., Hurrell, R.F., editors. Food Fortification in a Globalized World. Cambridge, MA: Academic Press. p. 241-246. https://doi.org/10.1016/B978-0-12-802861-2.00024-9.
DOI: https://doi.org/10.1016/B978-0-12-802861-2.00024-9 Interpretive Summary:
Technical Abstract: Flour fortification with folic acid, mandated for the prevention of neural tube defects, NTD can be regarded as a positive public health intervention especially for women of childbearing age. However, the denial of the possibility of adverse effects related to interaction between high folic acid intake and vitamin B12 deficiency or the possibility that folic acid fortification and/or supplementation may be associated with adverse effects in some elderly racial/genetic subgroups is a major concern that is being overlooked. Denying the existence of these adverse effects will prevent further and more methodological studies to understand the mechanism and risk of adverse effects of adding folic acid in substantial amounts to any nation's food supply by fortification and/or supplementation.