|HANNOU, SARAH - Duke University|
|HASLAM, DANIELLE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University|
|MCKEOWN, NICOLA - Jean Mayer Human Nutrition Research Center On Aging At Tufts University|
|HERMAN, MARK - Duke University|
Submitted to: Journal of Clinical Investigation
Publication Type: Review Article
Publication Acceptance Date: 12/2/2017
Publication Date: 2/1/2018
Citation: Hannou, S., Haslam, D.E., McKeown, N.M., Herman, M. 2018. Fructose metabolism and metabolic disease. Journal of Clinical Investigation. 128(2):545-555. https://doi.org/10.1172/JCI96702.
Technical Abstract: Increased sugar consumption is increasingly considered a contributor to the worldwide epidemics of obesity and diabetes and their associated cardiometabolic risks. As a result of its unique metabolic properties, the fructose component of sugar may be particularly harmful. Diets high in fructose can rapidly produce all of the key features of the metabolic syndrome. Here we review the biology of fructose metabolism as well as potential mechanisms by which excessive fructose consumption may contribute to cardiometabolic disease.