Submitted to: Genbank
Publication Type: Other
Publication Acceptance Date: 2/3/2017
Publication Date: N/A
Technical Abstract: Clostridium perfringens (CP) is ubiquitous in the nature, and a normal inhabitant in the intestinal tracts of animals and humans. However, pathogenic CP is also a causative agent of poultry disease necrotic enteritis (NE). Clostridium-related poultry diseases such as necrotic enteritis (NE) and gangrenous dermatitis (GD) cause substantial economic losses on a global scale. Two antigenic Clostridium perfringens proteins, elongation factor Tu (EF-Tu), was identified by reaction with immune sera from commercial meat-type chickens with clinical outbreak of Clostridium infections. Two major C. perfringens virulence factors in chickens are alpha-toxin and the NetB (necrotic enteritis B-like) toxin, both of which are implicated in the pathogenesis of NE, and presumably GD. Considerable insights into NE pathogenesis was provided recently that suggested that NE is caused by several novel virulence factors that are encoded by cluster of genes on a pathogenicity loci, and some of which are plasmid-born in nature.