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ARS Home » Northeast Area » Beltsville, Maryland (BARC) » Beltsville Agricultural Research Center » Animal Genomics and Improvement Laboratory » Research » Publications at this Location » Publication #346010
Title: A gene-transcription factor network associated with residual feed intake based on SNVs/InDels identified in Gir, Girolando and Holstein cattle breeds

Author
item VERARDO, LIMA - Embrapa
item STAFUZZA, NEDENIA - Universidade Estadual Paulista (UNESP)
item MUNARI, DANISIO - Universidade Estadual Paulista (UNESP)
item ZERLOTINI, ADHEMAR - Embrapa
item CHUD, TATIANE - Universidade Estadual Paulista (UNESP)
item GARRICK, DORIAN - Massey University
item Cole, John
item PANETTO, JOAO - Embrapa
item MACHADO, MARCOS - Embrapa
item MARTINS, MARTA - Embrapa
item DA SILVA, MARCOS - Embrapa

Submitted to: World Congress of Genetics Applied in Livestock Production
Publication Type: Proceedings
Publication Acceptance Date: 2/7/2018
Publication Date: 2/7/2018
Citation: Verardo, L.L., Stafuzza, N.B., Munari, D.P., Zerlotini, A., Chud, T.C., Garrick, D.J., Cole, J.B., Panetto, J., Machado, M.A., Martins, M.F., Da Silva, M.V. 2018. A gene-transcription factor network associated with residual feed intake based on SNVs/InDels identified in Gir, Girolando and Holstein cattle breeds. World Congress of Genetics Applied in Livestock Production. Feb. 11–16, Vol. Electron. Poster Sess.– Biol. & Species–Bovine (dairy) 1, p. 193.

Interpretive Summary:

Technical Abstract: A number of small DNA changes were recently identified in a group of Gir, Girolando, and Holstein cattle. Many of those DNA variants were associated with genes related to an animal’s sense of smell, and those genes may play a role in the amount of feed an animal eats. This study builds on that previous research by identifying transcription factor binding sites in the DNA of Gir, Girolando, and Holstein cattle. Transcription factor binding sites play a role in turning genes on and off. Interactions of candidate genes with transcription factor binding sites were examined, and several genes associated with feed intake were identified, including TRIM40, TBC1D7, and EPN3. The transcription factors STAT1 and MAX, which may have a role in explaining variation in feed intake, also were identified. The Gir and Girolando breeds showed more enriched genes in these networks, suggesting that they may have higher genetic variability for feed intake. The addition of these DNA variants to the genotypng panels routinely used for genomic evaluation could help decrease feed intake and increase dairy farm profitability.