Location: Emerging Pests and Pathogens ResearchTitle: Generation of novel resistance genes using mutation and targeted gene editing Author
Submitted to: Current Opinion in Virology
Publication Type: Review Article
Publication Acceptance Date: 7/3/2017
Publication Date: 8/9/2017
Citation: Gal-On, A., Fuchs, M., Gray, S.M. 2017. Generation of novel resistance genes using mutation and targeted gene editing. Current Opinion in Virology. 26:98-103. Interpretive Summary:
Technical Abstract: Classical breeding for virus resistance is a lengthy process and is restricted by the availability of resistance genes. Precise genome editing is a "dream technology" to improve plants for virus resistance and these tools have opened new and very promising ways to generate virus resistant plants by disrupting host susceptibility genes, or by increasing the expression of viral resistance genes. However, precise targets must be identified and their roles understood to minimize potential negative effects on the plant. Nonetheless, the opportunities for genome editing are expanding, as are the technologies to generate effective and broad-spectrum resistance against plant viruses. Here we provide insights into recent progress related to gene targets and gene editing technologies.