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ARS Home » Southeast Area » Athens, Georgia » U.S. National Poultry Research Center » Endemic Poultry Viral Diseases Research » Research » Publications at this Location » Publication #344141
Research Project: Intervention Strategies to Prevent and Control Enteric Diseases of Poultry

Location: Endemic Poultry Viral Diseases Research

Title: Isolation and genomic characterization of a novel avian orthoreovirus in Korea, 2014

Author
item NOH, JIN-YONG - Konkuk University
item LEE, DONG-HUN - Orise Fellow
item LIM, TAE-HYUN - Optipharm Co, Ltd
item LEE, JI-HO - Konkuk University
item Day, James
item SONG, CHANG-SEON - Konkuk University

Submitted to: Archives of Virology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 8/31/2017
Publication Date: 2/1/2018
Citation: Noh, J., Lee, D., Lim, T., Lee, J., Day, J.M., Song, C. 2018. Isolation and genomic characterization of a novel avian orthoreovirus in Korea, 2014. Archives of Virology. 163:1307-1316. https://doi.org/10.1007/s00705-017-3667-8.
DOI: https://doi.org/10.1007/s00705-017-3667-8

Interpretive Summary: Avian reoviruses (ARVs) cause viral arthritis, respiratory disease, hepatitis, myocarditis, immunosuppression, and malabsorption in chickens. In this study, we isolated a novel ARV strain, K738/14, from a broiler chicken with viral arthritis in South Korea in 2014. Genetic analysis suggested that the K738/14 virus is a reassortant virus between S1133, Hungarian, Chinese, and US origin strains. In addition, intra-segmental recombination in M2 and S2 genes were likely occurred. The emergence and evolution of K738/14 virus likely appear to have involved multiple reassortment, intra-segmental recombination, and genetic mutations.

Technical Abstract: In this study, we isolated a novel avian reovirus (ARV) strain, K738/14, from a broiler chicken with viral arthritis in South Korea. Genome sequence comparisons showed relatively low nucleotide identity with previously identified ARV strains. Phylogenetic analyses suggested multiple reassortment events between reovirus strain S1133 and reoviruses of Hungarian, Chinese, and US origin had occurred. In addition, recombination analyses showed evidence of intra-segmental recombination in the M2 and S2 genes. Based on our genetic analyses, multiple reassortment events, intra-segmental recombination, and accumulation of point mutations have possibly contributed to the emergence of this novel genotype of ARV, identified in Korea.