Location: Virus and Prion ResearchTitle: Draft genome sequences of 1 MSSA and 7 MRSA ST5 isolates obtained from California Author
Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/1/2017
Publication Date: 10/19/2017
Citation: Hau, S.J., Bayles, D.O., Alt, D.P., Nicholson, T.L. 2017. Draft genome sequences of one methicillin-sensitive and seven methicillin-resistant Staphylococcus aureus sequence type 5 Isolates obtained in California. Genome Announcements. 5(42):e01084-17.
Interpretive Summary: In the United States, a diverse population of livestock associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is found including organisms of the ST398, ST9, and ST5 lineages. Occurrence of ST5 MRSA in swine is of particular concern since ST5 is among the most prevalent lineages causing clinical infections in humans. The ability of ST5 isolates to cause disease in humans is believed to result from acquisition of mobile genetic elements encoding virulence or host-adapted genes. Here, we report the draft genome sequences for one methicillin sensitive S. aureus ST5 isolate and seven MRSA ST5 isolates obtained from patients with S. aureus related disease at the University of California San Francisco. This information can be directly used to search for mobile genetic elements encoding virulence or host-adapted genes. More importantly, the data reported here can be used to determine how genetically related are the ST5 isolates obtained from swine to ST5 isolates obtained from humans. This information is important to public health professional, veterinarians, producers, and consumers.
Technical Abstract: Staphylococcus aureus is a commensal of humans that can cause a spectrum of diseases. An isolate’s capacity to cause disease is partially attributed to the acquisition of novel mobile genetic elements. This report provides the draft genome sequence of one methicillin susceptible and seven methicillin resistant clinical human S. aureus isolates.