Location: Virus and Prion ResearchTitle: Draft genome sequences of 9 LA-MRSA ST5 isolates from humans with long term swine contact
|HAU, SAMANTHA - Iowa State University
|SUN, JISUN - University Of Minnesota
|DAVIES, PETER - University Of Minnesota
Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/1/2017
Publication Date: 10/12/2017
Citation: Hau, S.J., Bayles, D.O., Alt, D.P., Davies, P.R., Haan, J.S., Nicholson, T.L. 2017. Draft genome sequences of nine livestock-associated methicillin-resistant Staphylococcus aureus sequence type 5 isolates from humans with long-term swine contact. Genome Announcements. 5(41):e01079-17.
Interpretive Summary: Livestock associated methicillin-resistant Staphylococcus aureus (LA-MRSA) draws concern from the public health community because it is considered the largest reservoir of MRSA outside hospital settings. Swine populations in the US harbor a diverse population of LA-MRSA including organisms of the sequence type ST398, ST9, and ST5 lineages. Occurrence of ST5 MRSA in swine is of particular concern since ST5 is among the most prevalent lineages causing clinical infections in humans. The ability of ST5 isolates to cause disease in humans is believed to result from acquisition of mobile genetic elements encoding virulence or host-adapted genes. Here, we report the draft genome sequences of 9 LA-MRSA ST5 isolates from veterinarians with long term swine contact. This information can be directly used to search for mobile genetic elements encoding virulence or host-adapted genes. This information is important to public health professional, veterinarians, producers, and consumers.
Technical Abstract: Humans have been found to harbor livestock associated methicillin resistant Staphylococcus aureus (LA-MRSA) isolates. LA-MRSA are considered adapted to colonizing livestock and less pathogenic than their hospital and community counterparts. Here, we present 9 LA-MRSA ST5 isolates from veterinarians with long term swine contact.