|Reddy, Bobby - Purdue University|
|Salm, Eric - Purdue University|
|Bashir, Rashid - Purdue University|
Submitted to: Annals of Biomedical Engineering
Publication Type: Review Article
Publication Acceptance Date: 4/2/2016
Publication Date: 7/1/2016
Citation: Reddy, B., Salm, E., Bashir, R. 2016. Electrical chips for biological point-of-care detection. Annals of Biomedical Engineering. 18:329-355.
Technical Abstract: As the future of health care diagnostics moves toward more portable and personalized techniques, there is immense potential to harness the power of electrical signals for biological sensing and diagnostic applications at the point of care. Electrical biochips can be used to both manipulate and sense biological entities, as they can have several inherent advantages, including on-chip sample preparation, label-free detection, reduced cost and complexity, decreased sample volumes, increased portability, and large-scale multiplexing. The advantages of fully integrated electrical biochip platforms are particularly attractive for point-of-care systems, including on-site detection of harmful bacteria. This review summarizes these electrical lab-on-a-chip technologies and highlights opportunities to accelerate the transition from academic publications to commercial success.