|Weaveer, Connie - Purdue University|
|Dawson-hughes, Bess - Jean Mayer Human Nutrition Research Center On Aging At Tufts University|
|Lappe, Joan - Creighton University|
|Wallace, Taylor - National Osteoporosis Foundation|
Submitted to: Osteoporosis International
Publication Type: Other
Publication Acceptance Date: 2/4/2016
Publication Date: 3/18/2016
Citation: Weaveer, C.M., Dawson-Hughes, B., Lappe, J.M., Wallace, T.C. 2016. Re: errors in the NOF meta-analysis of calcium and vitamin D supplements. Osteoporosis International. doi: 10.1007/s00198-016-3525-7.
Technical Abstract: The manuscript entitled "Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation" sought to update a former AHRQ evidence report. The study was commissioned by the NOF to inform the organization, since a significant controversy exists regarding the effectiveness of supplemental calcium and vitamin D to prevent fractures. We chose to use the per protocol analyses data across studies to be consistent with the two former AHRQ evidence reports and to assess the actual effect of supplementation among individuals who were adherent throughout the duration of various studies included in the meta-analysis.