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ARS Home » Plains Area » Clay Center, Nebraska » U.S. Meat Animal Research Center » Nutrition and Environmental Management Research » Research » Publications at this Location » Publication #340931

Research Project: Improved Nutrient Efficiency of Beef Cattle and Swine

Location: Nutrition and Environmental Management Research

Title: Comparative gut physiology symposium: The microbe-gut-brain axis

Author
item Foote, Andrew

Submitted to: Journal of Animal Science
Publication Type: Proceedings
Publication Acceptance Date: 5/5/2017
Publication Date: 7/13/2017
Citation: Foote, A.P. 2017. Comparative gut physiology symposium: The microbe-gut-brain axis. Journal of Animal Science. 95(7):3214. doi: 10.2527/jas2017.1671.

Interpretive Summary:

Technical Abstract: The Comparative Gut Physiology Symposium titled “The Microbe-Gut-Brain Axis” was held at the Joint Annual Meeting of the American Society of Animal Science and the American Dairy Science Association on Thursday, July 21, 2016, in Salt Lake City Utah. The goal of the symposium was to present basic research conducted in the area of gut physiology with focus on the relationship between gut microbiota and health, stress, and neural function in humans as well as in health and production of livestock. From this symposium, 3 of the invited presentations were submitted as a review papers of the topics. Two of the speakers (G. Clarke and J. F. Cryan) combined their talks into a single paper for a total of 2 papers from this symposium. Dr. G. Clarke (University College of Cork, Ireland) presented a talk entitled “The gut microbiome as a regulator of physiology, brain, and behavior: Implications for the treatment of stress-related disorders”. Data presented focused on the role of the microbiome in the stress response and biochemical mechanisms by which the microbiome communicates with the brain (Wiley et al., 2017). Specifically, the role of gut microbiota on tryptophan metabolism was discussed with regard to serotonin production and other neuroactive compounds produced through the kynurenine pathway. Regulation of this metabolic pathway by the microbiota in the gut could provide a treatment for serotonin-related disorders such as depression. A follow-up talk was presented by Dr. J. F. Cryan (University College of Cork, Ireland) entitled “The microbiota-gut-brain axis: A key regulator of neural function across the life span”. This talk presented the developing body of literature on role of disruptions in the microbiome early in life on development of pathological conditions such as obesity (Wiley et al., 2017). Data was presented on the role of microbiota on anxiety- and depressive-like behavior in aging individuals. The impact of stress on the brain-microbiome axis was discussed as well as the role of gut microbiome on behavior. The final talk was presented by Dr. P. R. Myer (University of Tennessee, Knoxville) entitled “Analysis of the gut microbiome in beef cattle and its association with feed intake, growth, and efficiency”. Dr. Myer presented his extensive research on the microbiome throughout the gut of finishing beef cattle and the association of specific genera and operational taxonomic units with productions traits including feed intake, growth, and measures of feed efficiency (Myer et al., 2017). Data presented indicated that diversity of bacteria in the gut was not associated with production traits, but there were finer associations of bacteria with production traits. The Comparative Gut Physiology Symposium at the Joint Annual meeting has been well attended by a variety of scientists and students from multiple disciplines. The comparative nature of this symposium provides greater exposure of recent developments that could likely have application in a range of research areas.