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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #340367

Research Project: Genomics, Nutrition, and Health

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: MicroRNAs and drinking: association between the pre-miR-27a rs895819 polymorphism and alcohol consumption in a Mediterranean population

Author
item Barragan, Rocio - University Of Valencia
item Coltell, Oscar - University Jaume I Of Castellon
item Asensio, Eva - University Of Valencia
item Frances, Francesc - University Of Valencia
item Sorli, Jose - University Of Valencia
item Estruch, Ramon - Institut D'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS)
item Salas-huetos, Albert - University Rovira I Virgili
item Ordovas, Jose - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item Corella, Dolores - University Of Valencia

Submitted to: International Journal of Molecular Sciences
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 8/10/2016
Publication Date: 8/16/2016
Citation: Barragan, R., Coltell, O., Asensio, E.M., Frances, F., Sorli, J.V., Estruch, R., Salas-Huetos, A., Ordovas, J.M., Corella, D. 2016. MicroRNAs and drinking: association between the pre-miR-27a rs895819 polymorphism and alcohol consumption in a Mediterranean population. International Journal of Molecular Sciences. doi: 10.3390/ijms17081338.

Interpretive Summary: The discovery of very small RNAs known as microRNAs (miRNAs) have contributed to a more complete understanding of the regulation of our genes. Some of them have been proposed as regulators in the different processes involved in alcohol intake and metabolism, and differences have been found in the miRNA expression profile in alcoholics. However, no study has focused on analyzing polymorphisms in genes encoding miRNAs and daily alcohol consumption at the population level. Our aim was to investigate the association between a polymorphism in these miRNAs, known as the pre-miR-27a (rs895819 A>G) gene, and alcohol consumption in an elderly population. We undertook a cross-sectional study of PREvencion con DIeta MEDiterranea (PREDIMED)-Valencia participants (n = 1,007, including men and women aged 67 +/- 7 years) and measured their alcohol consumption (total and alcoholic beverages) through a validated questionnaire. We found a strong association between the pre-miR-27a polymorphism and total alcohol intake that was significantly higher in GG subjects compared to AG and AA subjects. We also found a statistically significant association of the pre-miR-27a polymorphism with the risk of having a high alcohol intake (>2 drinks/day in men and >1 in women:) 5.9% in AA versus 17.5% in GG. In conclusion, we report for the first time a significant association between a miRNA polymorphism (rs895819) and alcohol consumption.

Technical Abstract: Recently, microRNAs (miRNA) have been proposed as regulators in the different processes involved in alcohol intake, and differences have been found in the miRNA expression profile in alcoholics. However, no study has focused on analyzing polymorphisms in genes encoding miRNAs and daily alcohol consumption at the population level. Our aim was to investigate the association between a functional polymorphism in the pre-miR-27a (rs895819 A>G) gene and alcohol consumption in an elderly population. We undertook a cross-sectional study of PREvencion con DIeta MEDiterranea (PREDIMED)-Valencia participants (n = 1007, including men and women aged 67 +/- 7 years) and measured their alcohol consumption (total and alcoholic beverages) through a validated questionnaire. We found a strong association between the pre-miR-27a polymorphism and total alcohol intake, this being higher in GG subjects (5.2 +/- 0.4 in AA, 5.9 +/- 0.5 in AG and 9.1 +/- 1.8 g/day in GG; p(adjusted) = 0.019). We also found a statistically-significant association of the pre-miR-27a polymorphism with the risk of having a high alcohol intake (>2 drinks/day in men and >1 in women): 5.9% in AA versus 17.5% in GG; p(adjusted) <0.001. In the sensitivity analysis, this association was homogeneous for sex, obesity and Mediterranean diet adherence. In conclusion, we report for the first time a significant association between a miRNA polymorphism (rs895819) and daily alcohol consumption.