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Title: Global foot-and-mouth disease research update and gap analysis: 1 - overview of global status and research needs

Author
item KNIGHT-JONES, T.J.D - International Livestock Research Institute (ILRI) - Zambia
item ROBINSON, L. - Insight Editing London
item CHARLESTON, B. - The Pirbright Institute
item Rodriguez, Luis
item Gay, Cyril
item SUMPTION, K.J. - Food And Agriculture Organization Of The United Nations-European Commission For The Control Of Foot
item VOSLOO, W. - Australian Animal Health

Submitted to: Transboundary and Emerging Diseases
Publication Type: Review Article
Publication Acceptance Date: 4/2/2016
Publication Date: 4/2/2016
Citation: Knight-Jones, T., Robinson, L., Charleston, B., Rodriguez, L.L., Gay, C.G., Sumption, K., Vosloo, W. 2016. Global foot-and-mouth disease research update and gap analysis: 1 - overview of global status and research needs. Transboundary and Emerging Diseases. 63:3-13. doi: 10.1111/tbed.12528.

Interpretive Summary: The Global Foot-and-mouth disease (FMD) Research Alliance periodically reviews the state of FMD research to assess progress and to identify new priorities. In this supplement we provide an update of global FMD research, comprising (i) this overview paper, which includes background information with key findings, and papers covering (ii) epidemiology, wildlife and economics, (iii) vaccines, (iv) diagnostics, (v) biotherapeutics and disinfectants, (vi) immunology and (vii) pathogenesis and molecular biology. FMD research publications were reviewed (2011–2015) and activity updates were obtained from 33 FMD research institutes from around the world. Although a continual threat, FMD has been effectively controlled in much of the world using existing tools. However, control remains a challenge in most developing countries, where little has been done to understand the ongoing burden of FMD. More research is needed to support control in endemically infected countries, particularly robust field studies. Traditional FMD vaccines have several limitations including short duration and spectrum of protection, cold chain requirements, and the costs and biosecurity risks associated with vaccine production. Significant progress has been made in the development of novel vaccine candidates, particularly in the use of recombinant vaccines and virus-like particles as an alternative to traditional inactivated whole virus vaccines. Continued investment is needed to turn these developments into improved vaccines produced at scale. Increased knowledge of cellular and mucosal immunity would benefit vaccine development, as would further advances in our ability to enhance vaccine capsid stability. Developments in molecular biology and phylogenetics underlie many of the recent advances in FMD research, including improved vaccines and diagnostics, and improved understanding of FMD epidemiology. Tools for genetic analyses continue to become both more powerful and more affordable enabling them to be used to address an ever-expanding range of questions. This rapidly advancing field potentiates many areas of FMD research and should be prioritized.

Technical Abstract: Few, if any, animal diseases have a greater impact than footand-mouth disease (FMD). It is highly infectious, has enormous control costs and severe impacts on trade. FMD research is performed in numerous institutions around the world. The Global FMD Research alliance (GFRA) is an international consortium consisting of partners with recognized expertise in a range of advanced technologies and research capabilities in fields that are of potential strategic or commercial relevance to each other in terms of their interests in FMD. It aims to foster research cooperation and technical exchange to enhance each partner’s specific expertise; safely carry out research into FMD; promote knowledge and awareness in relation to FMD; and bring to bear the required cutting edge technologies that can deliver a new generation of FMD vaccines and related control strategies. Through collaboration, GFRA are the global leaders in scientific and technical knowledge for the detection, management and eradication of FMD, using economically viable approaches that are socially, and environmentally responsible. The GFRA vision is to expand the network of partners to include endemic regions that are not historically seen as major partners in FMD research.