|FERGUSON, JANE - Vanderbilt University|
|ALLAYEE, HOOMAN - University Of North Carolina|
|GERSZTEN, ROBERT - Harvard University|
|IDERAABDULLAH, FOLAMI - University Of North Carolina|
|KRIS-ETHERTON, PENNY - Pennsylvania State University|
|ORDOVAS, JOSE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University|
|RIMM, ERIC - Harvard University|
|WANG, THOMAS - Vanderbilt University|
|BENNETT, BRIAN - University Of North Carolina|
Submitted to: Circulation: Cardiovascular Genetics
Publication Type: Review Article
Publication Acceptance Date: 1/22/2016
Publication Date: 4/19/2016
Citation: Ferguson, J.F., Allayee, H., Gerszten, R.E., Ideraabdullah, F., Kris-Etherton, P.M., Ordovas, J.M., Rimm, E.B., Wang, T.J., Bennett, B.J. 2016. Nutrigenomics, the microbiome, and gene environment interactions: new directions in cardiovascular disease research, prevention, and treatment. A scientific statement From the American Heart Association. Circulation: Cardiovascular Genetics. 9(3):291-313.
Technical Abstract: Cardiometabolic diseases are the leading cause of death worldwide and are strongly linked to both genetic and nutritional factors. The field of nutrigenomics encompasses multiple approaches aimed at understanding the effects of diet on health or disease development, including nutrigenetic studies investigating the relationship between genetic variants and diet in modulating cardiometabolic risk, as well as the effects of dietary components on multiple “omic” measures, including transcriptomics, metabolomics, proteomics, lipidomics, epigenetic modifications, and the microbiome. Here, we describe the current state of the field of nutrigenomics with respect to cardiometabolic disease research and outline a direction for the integration of multiple omics techniques in future nutrigenomic studies aimed at understanding mechanisms and developing new therapeutic options for cardiometabolic disease treatment and prevention.