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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #332399

Research Project: Genomics, Nutrition, and Health

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Guide and position of the International Society of Nutrigenetics/Nutrigenomics on personalised nutrition: Part 1 - fields of precision nutrition

item FERGUSON, LYNNETTE - University Of Auckland
item DE CATERINA, RAFFAELE - University Of Chieti Pescara G D'Annunzio
item GORMAN, ULF - Lund University
item ALLAYEE, HOOMAN - University Of Southern California
item KOHLMEIER, MARTIN - University Of North Carolina
item PRASAD, CJAMDAM - Texas Woman'S University
item CHOI, MYUNG SOOK - Kyungpook National University
item CURI, RUI - Universidad De Sao Paulo
item DE LUIS, DANIEL ANTONIO - University Of Valladolid
item GIL, ANGEL - Universidad De Granada
item KANG, JING - Massachusetts General Hospital
item MARTIN, RON - Nutrigenetics Unlimited, Inc
item MILAGRO, FERMIN - University Of Navarra
item NICOLETTI, CAROLINA - Universidad De Sao Paulo
item NONINO, CARLA BARBOSA - Universidad De Sao Paulo
item ORDOVAS, JOSE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item PARSLOW, VIRGINIA - University Of Auckland
item PORTILLO, MARIA - University Of Basque Country
item SANTOS, JOSE LUIS - Pontifical Catholic University Of Chile
item SERHAN, CHARLES - Brigham & Women'S Hospital
item SIMOPOULOS, ARTEMIS - Center For Genetics, Nutrition And Health
item VELAZQUES-ARELLANO, ANTONIO - Universidad Nacional Autonoma De Mexico
item ZULET, MARIA ANGELES - University Of Navarra
item MARTINEZ, J ALFREDO - University Of Navarra

Submitted to: Jounal of Nutrigenetics and Nutrigenomics
Publication Type: Review Article
Publication Acceptance Date: 5/17/2015
Publication Date: 5/12/2016
Citation: Ferguson, L.R., De Caterina, R., Gorman, U., Allayee, H., Kohlmeier, M., Prasad, C., Choi, M., Curi, R., De Luis, D., Gil, A., Kang, J.X., Martin, R.L., Milagro, F.I., Nicoletti, C.F., Nonino, C., Ordovas, J.M., Parslow, V.R., Portillo, M.P., Santos, J., Serhan, C.N., Simopoulos, A.P., Velazques-Arellano, A., Zulet, M., Martinez, J. 2016. Guide and position of the International Society of Nutrigenetics/Nutrigenomics on personalised nutrition: Part 1 - fields of precision nutrition. Jounal of Nutrigenetics and Nutrigenomics. 9:12-27.

Interpretive Summary:

Technical Abstract: Diversity in the genetic profile between individuals and specific ethnic groups affects nutrient requirements, metabolism and response to nutritional and dietary interventions. Indeed, individuals respond differently to lifestyle interventions (diet, physical activity, smoking, etc.). The sequencing of the human genome and subsequent increased knowledge regarding human genetic variation is contributing to the emergence of personalized nutrition. These advances in genetic science are raising numerous questions regarding the mode that precision nutrition can contribute solutions to emerging problems in public health, by reducing the risk and prevalence of nutrition related diseases. Current views on personalized nutrition encompass omics technologies (nutrigenomics, transcriptomics, epigenomics, foodomics, metabolomics, metagenomics, etc.), functional food development and challenges related to legal and ethical aspects, application in clinical practice, and population scope, in terms of guidelines and epidemiological factors. In this context, precision nutrition can be considered as occurring at three levels: (1) conventional nutrition based on general guidelines for population groups by age, gender and social determinants; (2) individualized nutrition that adds phenotypic information about the person’s current nutritional status (e.g. anthropometry, biochemical and metabolic analysis, physical activity, among others), and (3) genotype directed nutrition based on rare or common gene variation. Research and appropriate translation into medical practice and dietary recommendations must be based on a solid foundation of knowledge derived from studies on nutrigenetics and nutrigenomics. A scientific society, such as the International Society of Nutrigenetics/Nutrigenomics (ISNN), internationally devoted to the study of nutrigenetics/nutrigenomics, can indeed serve the commendable roles of (1) promoting science and favoring scientific communication and (2) permanently working as a ‘clearing house’ to prevent disqualifying logical jumps, correct or stop unwarranted claims, and prevent the creation of unwarranted expectations in patients and in the general public. In this statement, we are focusing on the scientific aspects of disciplines covering nutrigenetics and nutrigenomics issues. Genetic screening and the ethical, legal, social and economic aspects will be dealt with in subsequent statements of the Society.