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ARS Home » Pacific West Area » Logan, Utah » Poisonous Plant Research » Research » Publications at this Location » Publication #332038
Title: Elimination of the tremorgenic toxin of Ipomoea asarifolia by milk

Author
item LOPES, JOSE - Veterinary Hospital, Federal University Of Campina Grande (UFCG)
item RIET-CORREA, FRANKLIN - Veterinary Hospital, Federal University Of Campina Grande (UFCG)
item Cook, Daniel
item Pfister, James
item MEDEIROS, ROSANE - Veterinary Hospital, Federal University Of Campina Grande (UFCG)

Submitted to: Pesquisa Veterinaria Brasileira
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 10/22/2014
Publication Date: 11/1/2014
Publication URL: http://handle.nal.usda.gov/10113/5394137
Citation: Lopes, J.R., Riet-Correa, F., Cook, D., Pfister, J.A., Medeiros, R.M. 2014. Elimination of the tremorgenic toxin of Ipomoea asarifolia by milk. Pesquisa Veterinaria Brasileira. 34(11):1085-1088.

Interpretive Summary: With the aim to determine if the tremorgenic toxin of Ipomoea asarifolia is eliminated in milk, three groups of Swiss female mice received, immediately after giving birth until weaning, a ration containing 20% or 30% of dry I. asarifolia. All the offspring of the females that received 20% or 30% I. asarifolia showed tremors 2-4 days after birth. The offspring of the females that received 20% I. asarifolia recovered 4-7 days after weaning. The offspring of the females that received 30% of the plant in the ration died while showing tremors before weaning or up to two days after weaning. It is concluded that the tremorgenic compound of I. asarifolia or its toxic metabolites are eliminated in milk. Lactating mice may be used as a model for the determination of the toxic compound(s) in this plant.

Technical Abstract: With the aim to determine if the tremorgenic toxin of Ipomoea asarifolia is eliminated in milk, three groups of Swiss female mice received, immediately after giving birth until weaning, a ration containing 20% or 30% of dry I. asarifolia. All the offspring of the females that received 20% or 30% I. asarifolia showed tremors 2-4 days after birth. The offspring of the females that received 20% I. asarifolia recovered 4-7 days after weaning. The offspring of the females that received 30% of the plant in the ration died while showing tremors before weaning or up to two days after weaning. It is concluded that the tremorgenic compound of I. asarifolia or its toxic metabolites are eliminated in milk, and that lactating mice may be used as a model for the determination of the toxic compound(s) in this plant.