|Hruby, Adela - JEAN MAYER HUMAN NUTRITION RESEARCH CENTER ON AGING AT TUFTS UNIVERSITY|
|Mckeown, Nicola - JEAN MAYER HUMAN NUTRITION RESEARCH CENTER ON AGING AT TUFTS UNIVERSITY|
Submitted to: Nutrition Today
Publication Type: Review Article
Publication Acceptance Date: 11/2/2015
Publication Date: 6/1/2016
Citation: Hruby, A., Mckeown, N.M. 2016. Magnesium deficiency: What is our status. Nutrition Today. 51(3):121-128.
Technical Abstract: Low magnesium intake has been implicated in a broad range of cardiometabolic conditions, including diabetes, hypertension, and cardiovascular disease. Dietary magnesium and total body magnesium status have a widely-used but imperfect biomarker in serum magnesium. Despite serum magnesium’s limitations, it is nevertheless observed to be lower in those with cardiometabolic disease than in generally healthy people. Although some 50% of Americans do not meet recommended levels of magnesium intake, the extent of prevalent magnesium deficiency is unknown. Given magnesium’s role in a multitude of chronic conditions which are increasingly common across the globe, here we summarize recently published literature reporting prevalent hypomagnesaemia in generally representative populations, and in populations with type 2 diabetes, metabolic syndrome, and obesity. On the basis of these studies, we estimate that up to a third of the general population may be magnesium deficient, and that outside of acute clinical encounters or hospitalization, hypomagnesaemia is likely frequently overlooked in general clinical practice.