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ARS Home » Pacific West Area » Logan, Utah » Poisonous Plant Research » Research » Publications at this Location » Publication #331321

Title: Increased susceptibility to atrial fibrillation secondary to atrial fibrosis in transgenic goats expressing transforming growth factor - B1

item POLEJAEVA, IRINA - Utah State University
item RANJAN, RAVI - University Of Utah
item DAVIES, CHRISTOPHER - Utah State University
item REGOUSKI, MISHA - Utah State University
item HALL, JUSTIN - Utah State University
item OLSEN, AARON - Utah State University
item MENG, QINGGANG - Utah State University
item RUTIGLIANO, HELOISA - Utah State University
item DOSDALL, DEREK - University Of Utah
item ANGEL, NATHAN - University Of Utah
item SACHSE, FRANK - University Of Utah
item SEIDEL, THOMAS - University Of Utah
item THOMAS, AARON - Utah State University
item STOTT, RUSTY - Utah State University
item Panter, Kip
item LEE, PAMELA - Washington State University
item VANWETTERE, ARNAUD - Utah State University
item STEVENS, JOHN - Utah State University
item WANG, ZHONGDE - Utah State University
item MACLEOD, ROB - University Of Utah
item MARROUCHE, NASSIR - University Of Utah
item WHITE, KENNETH - Utah State University

Submitted to: Electronic Publication
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 6/17/2016
Publication Date: N/A
Citation: N/A

Interpretive Summary: Animal models to study human disease conditions are essential if progress to be made in the treatment of these conditions. One of these disease conditions is atrial fibrillation (AF) in people. AF is the most common sustained heart arrhythmia with significant negative impact on human health and a high death rate. In people, the prevalence of AF increases with age developing slowly over many decades of life. This is the first study to generate a goat model with specific targeted sensitivity to AF. This study will open new avenues for research into the treatment and prevention of AF in people.

Technical Abstract: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in people with significant morbidity and mortality. There is a strong association between atrial fibrosis and AF. Transforming growth factor B1 (TGF-B1) is an essential mediator of atrial fibrosis in animal models and human patients. This is the first study to generate a transgenic goat model with TGF-B1-induced atrial fibrosis leading to increased AF susceptibility. As research progresses, this goat model will provide novel methods to study AF in people and subsequently provide better options for treatment and prevention of this disease.