|Cheng, Luisa Wai Wai|
|Singh, Bal Ram|
Submitted to: Toxins
Publication Type: Review Article
Publication Acceptance Date: 1/7/2017
Publication Date: 1/18/2017
Citation: Peck, M.W., Smith, T.J., Anniballi, F., Arnon, S.S., Austin, J.W., Bano, L., Bradshaw, M., Cuervo, M.P., Cheng, L.W., Derman, Y., Dorner, B., Dover, N., Fischer, A., Hill, K.K., Kalb, S., Korkeala, H., Lindstrom, M., Lista, F., Luquez, C., Mazuet, C., Pellett, S., Pirazzini, M., Popoff, M.R., Rasetti-Escargueil, C., Rossetto, O., Rummel, A., Sesardic, T., Singh, B., Stringer, S.C. 2017. Historical perspectives and guidelines for botulinum neurotoxin subtype nomenclature. Toxins. 9(1):E38. doi:10.3390/toxins9010038. Interpretive Summary: There are at least seven botulinum neurotoxins and 40 known subtypes of these toxins. Many new toxin subtypes are continuously being discovered worldwide. In order to prevent confusion and repetition in the naming of newly discovered toxins, a committee of scientists from the botulinum community was convened to develop new naming guidelines. This manuscript describes the history of how botulinum neurotoxins have been named and classified, and sets out new guidelines and criteria for the future naming of new toxin serotypes or subtypes.
Technical Abstract: Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which presents challenges when organizing the nomenclature surrounding these neurotoxins. Worldwide, researchers are faced with the possibility that toxins having identical sequences may be given different designations, or novel toxins having unique sequences may be given the same designations on publication. In order to minimize these problems, an ad hoc committee consisting of over 20 researchers in the field of botulinum neurotoxin research was convened to discuss clarification of the issues involved in botulinum neurotoxin nomenclature. This publication presents a historical overview of the issues and provides guidelines for botulinum neurotoxin nomenclature in the future.