Page Banner

United States Department of Agriculture

Agricultural Research Service

Research Project: Advance the Development of Technologies for Detecting and Determining the Stability and Bioavailability of Toxins that Impact Food Safety and Food Defense

Location: Foodborne Toxin Detection and Prevention Research

Title: Historical perspectives and guidelines for botulinum neurotoxin subtype nomenclature

item Peck, Michael
item Smith, Teresa
item Anniballi, Fabrizio
item Arnon, Stephen
item Austin, John
item Bano, Luca
item Bradshaw, Marite
item Cuervo, Maria
item Cheng, Luisa Wai Wai
item Derman, Yagmur
item Dorner, Brigitte
item Dover, Nir
item Fischer, Audrey
item Hill, Karen
item Kalb, Suzanne
item Korkeala, Hannu
item Lindstrom, Mia
item Lista, Florigio
item Luquez, Carolina
item Mazuet, Christelle
item Pellett, Sabine
item Pirazzini, Marco
item Popoff, Michel
item Rasetti-escargueil, Christine
item Rossetto, Ornella
item Rummel, Andreas
item Sesardic, Thea
item Singh, Bal Ram
item Stringer, Sandra

Submitted to: Toxins
Publication Type: Review Article
Publication Acceptance Date: 1/7/2017
Publication Date: 1/18/2017
Citation: Peck, M.W., Smith, T.J., Anniballi, F., Arnon, S.S., Austin, J.W., Bano, L., Bradshaw, M., Cuervo, M.P., Cheng, L.W., Derman, Y., Dorner, B., Dover, N., Fischer, A., Hill, K.K., Kalb, S., Korkeala, H., Lindstrom, M., Lista, F., Luquez, C., Mazuet, C., Pellett, S., Pirazzini, M., Popoff, M.R., Rasetti-Escargueil, C., Rossetto, O., Rummel, A., Sesardic, T., Singh, B., Stringer, S.C. 2017. Historical perspectives and guidelines for botulinum neurotoxin subtype nomenclature. Toxins. 9(1):38. doi: 10.3390/toxins9010038.

Interpretive Summary: There are at least seven botulinum neurotoxins and 40 known subtypes of these toxins. Many new toxin subtypes are continuously being discovered worldwide. In order to prevent confusion and repetition in the naming of newly discovered toxins, a committee of scientists from the botulinum community was convened to develop new naming guidelines. This manuscript describes the history of how botulinum neurotoxins have been named and classified, and sets out new guidelines and criteria for the future naming of new toxin serotypes or subtypes.

Technical Abstract: Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which presents challenges when organizing the nomenclature surrounding these neurotoxins. Worldwide, researchers are faced with the possibility that toxins having identical sequences may be given different designations, or novel toxins having unique sequences may be given the same designations on publication. In order to minimize these problems, an ad hoc committee consisting of over 20 researchers in the field of botulinum neurotoxin research was convened to discuss clarification of the issues involved in botulinum neurotoxin nomenclature. This publication presents a historical overview of the issues and provides guidelines for botulinum neurotoxin nomenclature in the future.

Last Modified: 09/22/2017
Footer Content Back to Top of Page