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ARS Home » Southeast Area » Athens, Georgia » U.S. National Poultry Research Center » Endemic Poultry Viral Diseases Research » Research » Publications at this Location » Publication #328918

Research Project: GENOMIC STRATEGIES FOR CONTROL OF HERPESVIRUSES OF POULTRY

Location: Endemic Poultry Viral Diseases Research

Title: African swine fever virus serotype-specific proteins are significant protective antigens for African swine fever

Author
item Burmakina, G - State Research Of Virology And Biotechnology (VECTOR INSTITUTE)
item Malogolovkin, A - State Research Of Virology And Biotechnology (VECTOR INSTITUTE)
item Tulman, E.r. - University Of Connecticut
item Zsak, Laszlo
item Delhon, G - University Of Nebraska
item Diel, D.g - University Of Illinois
item Shobogorov, N.m. - State Research Of Virology And Biotechnology (VECTOR INSTITUTE)
item Morgunov, Y.p - State Research Of Virology And Biotechnology (VECTOR INSTITUTE)
item Morgunov, S.y - State Research Of Virology And Biotechnology (VECTOR INSTITUTE)
item Kutish, G.f - University Of Connecticut
item Kolbasov, D - State Research Of Virology And Biotechnology (VECTOR INSTITUTE)
item Rock, D.l. - University Of Illinois

Submitted to: Journal of General Virology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 4/25/2016
Publication Date: 7/1/2016
Citation: Burmakina, G., Malogolovkin, A., Tulman, E., Zsak, L., Delhon, G., Diel, D., Shobogorov, N., Morgunov, Y., Morgunov, S., Kutish, G., Kolbasov, D., Rock, D. 2016. African swine fever virus serotype-specific proteins are significant protective antigens for African swine fever. Journal of General Virology. 97:1670-1675. DOI: 10.1099/jgv.0.000490.
DOI: https://doi.org/10.1099/jgv.0.000490

Interpretive Summary: African swine fever (ASF) is an emerging disease threat for the swine industry worldwide and no ASF vaccine is available. Data indicate that ASF protective immunity may be serotype-specific. Here, using ASF virus inter serotypic chimeric viruses and vaccination/challenge experiments in pigs, we demonstrate that serotype-specific CD2v and/or C-type lectin proteins are important for protection against homologous ASFV infection. Thus, these viral proteins represent significant protective antigens for ASF virus that should be targeted in future vaccine design and development.

Technical Abstract: African swine fever (ASF) is an emerging disease threat for the swine industry worldwide. No ASF vaccine is available and progress is hindered by lack of knowledge concerning the extent of ASFV strain diversity and the viral antigens conferring type-specific protective immunity in pigs. Available data from vaccination/challenge experiments in pigs indicate that ASF protective immunity may be haemadsorption inhibition (HAI) serotype-specific. Recently, we have shown that two ASFV proteins, CD2v (EP402R) and C-type lectin (EP153R), are necessary and sufficient for mediating HAI serological specificity (Malogolovkin et al., 2015).. Here, using ASFV inter-serotypic chimeric viruses and vaccination/challenge experiments in pigs, we demonstrate that serotype-specific CD2v and/or C-type lectin proteins are important for protection against homologous ASFV infection. Thus, these viral proteins represent significant protective antigens for ASFV that should be targeted in future vaccine design and development. Additionally, these data support the concept of HAI serotype-specific protective immunity.