|Poulose, Shibu - Jean Mayer Human Nutrition Research Center On Aging At Tufts University|
Submitted to: NeuroMolecular Medicine
Publication Type: Review Article
Publication Acceptance Date: 4/28/2016
Publication Date: 8/16/2016
Citation: Thangthaeng, N., Poulose, S.M., Miller, M.G., Shukitt Hale, B. 2016. Preserving brain function in aging: the anti-glycative potential of berry fruit. NeuroMolecular Medicine. 18:465-473, doi: 10.1007/s12017-016-8400-3.
Technical Abstract: Advanced glycation end-products (AGEs) are naturally occurring macromolecules that are formed in vivo by the non-enzymatic modification of proteins, lipids, or nucleic acids by sugar, even in the absence of hyperglycemia. In the diet, AGEs are found in animal products, and additional AGEs are produced when those foods are cooked at high temperatures. Studies have linked AGEs to various age-related physiological changes, including wrinkles, diabetic complications, and neurodegenerative disease, including Alzheimer’s disease. Dietary berry fruits have been shown to reduce the severity or slow the progression of many physiological changes and disease pathologies that accompany aging. Emerging evidence has shown that the phytochemicals found in berry fruits exhibit anti-glycative activity. In this review, we briefly summarize the current evidence supporting the neuroprotective anti-glycative activity of berry fruits and their potential to preserve cognitive function during aging.